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Synfacts 2007(10): 1073-1073  
DOI: 10.1055/s-2007-969014
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Chiral Counterion Strategy for Asymmetric Transition-Metal Catalysis

Contributor(s): Hisashi Yamamoto, Matthew B. Boxer
G. L. Hamilton, E. J. Kang, M. Mba, F. D. Toste*
University of California at Berkeley, USA
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Publication History

Publication Date:
07 November 2007 (online)

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Significance

The Toste group has continued their distinct work in the arena of Au(I)-catalyzed asymmetric reactions. This paper presents interesting findings in the role of the counteranion in which a chiral counteranion (not ligand) provides high selectivity for hydroalkoxylation and hydro­amination reactions of allenes. The hydrocarbox­ylation of allenes was best accomplished with both chiral ligand and chiral counteranion used in conjunction.