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Synthesis 2007(12): 1861-1871
DOI: 10.1055/s-2007-983704
DOI: 10.1055/s-2007-983704
PAPER
© Georg Thieme Verlag Stuttgart · New York
Chlorotrimethylsilane-Mediated Synthesis of Functionalized Fused Pyridines: Reaction of 3-Formylchromones with Electron-Rich Aminoheterocycles
Further Information
Received
2 March 2007
Publication Date:
08 June 2007 (online)
Publication History
Publication Date:
08 June 2007 (online)
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Abstract
The reaction of 3-formylchromones with aminoheterocycles was investigated. A simple and flexible general procedure for annulation of 5-(2-hydroxybenzoyl)pyridines was proposed. The best reaction conditions were found to be heating the reaction mixture in DMF in the presence of Me3SiCl as a promoter and water as scavenger.
Key words
3-formylchromones - aminoheterocycles - anilines - fused pyridines - quinolines - cyclization - chlorotrimethylsilane
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