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Synfacts 2008(1): 0012-0012  
DOI: 10.1055/s-2007-992390
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Neooxazolomycin

Contributor(s): Philip Kocienski, Stewart Eccles
E. O. Onyango, J. Tsurumoto, N. Imai, K. Takahashi, J. Ishihara, S. Hatakeyama*
Nagasaki University, Japan
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Publication History

Publication Date:
18 December 2007 (online)

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Significance

Neooxazolomycin is a member of a group of antibiotics that contain the oxazole-polyene-lactam-lactone motifs. Neooxazolomycin exhibits a range of activities including antibiotic, antiviral, and antitumor properties. The present synthesis features an intramolecular Tamao hydro­silylation (A to B) to generate a trisubstituted alkene stereospecifically.