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Synfacts 2008(3): 0277-0277  
DOI: 10.1055/s-2008-1042681
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

TRISPHAT-N Anion Provides Bench-Stable Ruthenium Catalyst

Contributor(s): Hisashi Yamamoto, Joshua N. Payette
S. Constant, S. Tortoioli, J. Müller, D. Linder, F. Buron, J. Lacour*
University of Geneva, Switzerland
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Publikationsdatum:
21. Februar 2008 (online)

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Significance

Asymmetric ruthenium catalysis is useful for the preparation of chiral allylic compounds through nucleophilic attack at the more substituted position of an allyl-ruthenium fragment. However, these reactions require large amounts (10 mol%) of Cp*Ru type catalysts which are difficult to recover owing to their sensitivity to oxygen and moisture. The present study reports that air- and moisture-stable Cp*Ru complexes are achievable through the use of the anionic monodentate ligand TRISPHAT-N.