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Synfacts 2008(3): 0265-0265  
DOI: 10.1055/s-2008-1042692
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Application of DYKAT to Au(I)-Catalyzed Hydroamination of Allenes

Contributor(s): Mark Lautens, Praew Thansandote
Z. Zhang, C. F. Bender, R. A. Widenhoefer*
Duke University, Durham, USA
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Publikationsdatum:
21. Februar 2008 (online)

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Significance

This report illustrates the first examples of dynamic kinetic enantioselective hydroaminations of axially chiral allenes. Though the scope is modest and the Z:E selectivities and enantioselectivities are poor for some examples, the authors have obtained good evidence for the dynamic nature of this process through kinetic studies.