Catalytic Asymmetric Allylic Alkylation with Vinylaluminum Reagents

doi:10.1055/s-2008-1042697

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Synfacts 2008(3): 0267-0267
DOI: 10.1055/s-2008-1042697

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Catalytic Asymmetric Allylic Alkylation with Vinylaluminum Reagents

Contributor(s): Mark Lautens, Valentina Aureggi
Y. Lee, K. Akiyama, D. G. Gillingham, M. K. Brown, A. H. Hoveyda*
Boston College, Chestnut Hill, USA

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Publication History

Publication Date:
21 February 2008 (online)

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Significance

A new efficient method for catalytic asymmetric allylic alkylation of allylic phosphates with vinylaluminum reagents is reported. The desired products are obtained in good yields and with enantioselectivities up to 98% ee.