Convenient and General Iron-Catalyzed Hydrosilylation of Aldehydes

doi:10.1055/s-2008-1042729

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Synfacts 2008(3): 0295-0295
DOI: 10.1055/s-2008-1042729

Metal-Mediated Synthesis

Convenient and General Iron-Catalyzed Hydrosilylation of Aldehydes

Contributor(s): Paul Knochel, Andrei Gavryushin
N. S. Shaikh, K. Junge, M. Beller*
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Germany

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Publikationsdatum:
21. Februar 2008 (online)

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Significance

This publication describes a general and chemoselective method for the iron-catalyzed hydrosilylation of aldehydes. Inexpensive PMHS (polymethylhydrosiloxane) is used as a hydride source. Simple hydrolysis leads directly to the corresponding alcohols, thus giving a synthetically useful aldehyde reduction method. Besides, it is an interesting and very spectacular example of an unusually strong influence of a phosphorus ligand in a reaction, catalyzed by a low-valent iron species.