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Synfacts 2008(4): 0397-0397  
DOI: 10.1055/s-2008-1042789
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Aluminum-Catalyzed Enantioselective Passerini Reaction

Contributor(s): Mark Lautens, Valentina Aureggi
S.-X. Wang, M.-X. Wang*, D.-X. Wang, J. Zhu*
Chinese Academy of Sciences, Beijing, P. R. of China and Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France
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Publikationsdatum:
19. März 2008 (online)

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Significance

The development of an enantio­selective three-component [(salen)Al(III)Cl] catalyzed Passerini reaction is reported. The desired α-acyl­oxyamides are obtained with good to excellent enantioselectivities in moderate to good yields. For previous work, see: S. X. Wang, M. X. Wang, D. X. Wang, J. Zhu Eur. J. Org. Chem. 2007, 4076. For further multicomponent reactions, see the review below.