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Synfacts 2008(4): 0382-0382  
DOI: 10.1055/s-2008-1042868
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Ruthenium-Catalyzed Enantioselective Hydrogenation of Pyrroles

Contributor(s): Hisashi Yamamoto, Pingfan Li
R. Kuwano*, M. Kashiwabara, M. Ohsumi, H. Kusano
Kyushu University, Fukuoka, Japan
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Publikationsverlauf

Publikationsdatum:
19. März 2008 (online)

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Significance

Enantioselective hydrogenation of pyrroles would provide direct access to chiral ­pyrrolidine rings. The current work succeeded in ­using 2,3,5-trisubstituted pyrroles as substrate to give all-cis pyrrolidine products with three chiral centers, or chiral 4,5-dihydropyrroles. Basically, this method is a powerful entry to chiral pyrrolidine, very useful for pharmaceutical applications as well as organocatalysis.