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Synfacts 2008(4): 0337-0337  
DOI: 10.1055/s-2008-1042888
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Nemorosone and Clusianone

Contributor(s): Philip Kocienski, Indu Dager
C. Tsukano, D. R. Siegel, S. J. Danishefsky*
Memorial Sloan-Kettering Cancer Center and Columbia University, New York, USA
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Publication History

Publication Date:
19 March 2008 (online)

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Significance

Nemorosone and clusianone belong to the family of acylphloroglucinols and are isolated from Clusia rosea and Clusia congestiflora, respectively. Nemorosone inhibits telomerase and ERK-1/2. They were constructed from the same intermediate, D, which was prepared by an iodonium-induced carbocyclization. This synthesis is distinguished for the use of non-conventional carbanions in several steps.