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Synfacts 2008(6): 0605-0605  
DOI: 10.1055/s-2008-1072619
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Enantioselective Niobium-Catalyzed Aza-Diels-Alder Reaction of Danishefsky’s Diene

Contributor(s): Hisashi Yamamoto, Cheol Hong Cheon
V. Jurík, K. Arai, M. M. Salter, Y. Yamashita, S. Kobayashi*
The University of Tokyo, Japan
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Publikationsdatum:
21. Mai 2008 (online)

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Significance

The authors report the first enan­tioselective aza-Diels-Alder reaction of imines with Danishefsky’s diene catalyzed by a niobium-based chiral Lewis acid. It should be noted that high yields and high enantioselectivities were obtained with both aromatic and aliphatic imines.