Vanadium-Catalyzed Asymmetric Transcyanation of Aliphatic Aldehydes

doi:10.1055/s-2008-1072628

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Synfacts 2008(6): 0616-0616
DOI: 10.1055/s-2008-1072628

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Vanadium-Catalyzed Asymmetric Transcyanation of Aliphatic Aldehydes

Contributor(s): Hisashi Yamamoto, Joshua P. Abell
J. Takaki, H. Egami, K. Matsumoto, B. Saito, T. Katsuki*
Kyushu University, Fukuoka, Japan

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Publication History

Publication Date:
21 May 2008 (online)

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Significance

Utilizing a non-conventional cyanide source to produce cyanohydrins the authors report a highly enantioselective method for aliphatic aldehydes. Continuing their investigation of the reduced salen ligand derivatives (salalen) the reaction was found to be sensitive to a number of factors including temperature and substrate choice.