Dithiane Hydrolysis by a Polymer-Supported Iodate

Significance

The first solid-phase-assisted protocol for the hydrolysis of dithioacetals with three kinds of functionalized ion-exchange resins was described. Thus, the reaction of 1 with resin-supported 2 (4-10 mol equiv) in aqueous MeCN at room temperature for 0.5-1 hour followed by scavenging CF₃CO₂H with resin-supported 3 4-10 mol equiv) and removing dithiolane 8 with resin-supported 4 (4-10 mol equiv) afforded 5a-d in 83-94% yield. Additional purification was not necessary for the isolation of 5.