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Synfacts 2008(8): 0783-0783  
DOI: 10.1055/s-2008-1077896
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-β-Caryophyllene

Contributor(s): Philip Kocienski, Arndt W. Schmidt
O. V. Larionov, E. J. Corey*
Harvard University, Cambridge, USA
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Publikationsverlauf

Publikationsdatum:
23. Juli 2008 (online)

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Significance

The synthesis of β-caryophyllene and coraxenolide A by Larionov and Corey is distinctive because it is a rare example of the use of planar chirality in natural product synthesis. Both enantiomers of (2Z,6E)-6-methylcyclonona-2,6-dienone (H) were prepared and used as chiral precursors for the synthesis of the (-)-β-caryophyllene and coraxeniolide A.