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Synfacts 2008(9): 0903-0903  
DOI: 10.1055/s-2008-1077994
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Clausamines A-C

Contributor(s): Philip Kocienski, Indu Dager
T. P. Lebold, M. A. Kerr*
The University of Western Ontario, London, Canada
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Publication History

Publication Date:
22 August 2008 (online)

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Significance

Clausamines A-C are isolated from the Clausena anisata while clausevatines D-G and clausamines D-G were isolated from the root bark of Clausena excavata, which is used as a folk medicine for the treatment of snakebites, abdominal pain and as a detoxificant. The first total syntheses of clausamines A-C are reported here.