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Synfacts 2008(9): 0956-0956  
DOI: 10.1055/s-2008-1078006
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalyzed Asymmetric Baeyer-Villiger Oxidation

Contributor(s): Hisashi Yamamoto, Cheol Hong Cheon
A. V. Malkov*, F. Friscourt, M. Bell, M. E. Swarbrick, P. Kočovský*
University of Glasgow and GlaxoSmithKline, Harlow, UK
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Publikationsverlauf

Publikationsdatum:
22. August 2008 (online)

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Significance

The authors reported the asymmetric Baeyer-Villiger oxidation of symmetrical cyclo­butanones with urea-hydrogen peroxide in the presence of Pd(II) and a new terpene-derived
P,N-ligand. The resulting lactones were obtained in high yields and with good enantioselectivities.