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Synfacts 2008(9): 0955-0955  
DOI: 10.1055/s-2008-1078009
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Chiral Spiroborate-Catalyzed Borane Reduction of Ketoxime Ethers

Contributor(s): Hisashi Yamamoto, Pingfan Li
K. Huang, F. G. Merced, M. Ortiz-Marciales*, H. J. Meléndez, W. Correa, M. De Jesús
University of Puerto Rico-Humacao, Puerto Rico
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Publikationsverlauf

Publikationsdatum:
22. August 2008 (online)

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Significance

This work provides a good method for the preparation of various chiral amines. The previous difficulties in using oxime ether as substrates are solved through the adoption of a spiro­borate ester as catalyst. The high chemical yields and enantiomeric excesses obtained are very attractive for future applications.