New Ligands for Copper-Catalyzed Friedel-Crafts
Reactions of Indoles

S. Nakamura; K. Hyudo; Y. Nakamura; N. Shibata; T. Toru

doi:10.1055/s-2008-1078122

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Synfacts 2008(10): 1061-1061
DOI: 10.1055/s-2008-1078122

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

New Ligands for Copper-Catalyzed Friedel-Crafts Reactions of Indoles

Contributor(s): Mark Lautens, Praew Thansandote
S. Nakamura*, K. Hyudo, Y. Nakamura, N. Shibata, T. Toru*
Nagoya Institute of Technology, Japan

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Publikationsdatum:
22. September 2008 (online)

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Significance

A new class of bis(imidazoline) ligands, related to the pybox family, are used for the Cu-catalyzed enantioselective Friedel-Crafts alkylation of indoles. Both enantiomers of product can be synthesized depending on the ligand, which can also be used as chiral Brønsted acids in combination with achiral acids.