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Synfacts 2008(10): 1067-1067
DOI: 10.1055/s-2008-1078141
DOI: 10.1055/s-2008-1078141
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Novel Dirhodium Catalyst for Enantio-selective C-H Amination
D. N. Zalatan, J. Du Bois*
Stanford University, USA
Further Information
Publication History
Publication Date:
22 September 2008 (online)
Significance
In this latest report, Du Bois’ group introduces a unique valerolactam-derived dirhodium catalyst for intramolecular C-H amination. This novel catalyst provides the highest levels of enantioselectivity observed for the transition-metal-catalyzed C-H amination of sulfamate esters. Another significant feature of this protocol is the high level of chemoselectivity observed for the homoallyl sulfamate substrates.