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Synfacts 2008(10): 1067-1067  
DOI: 10.1055/s-2008-1078141
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Novel Dirhodium Catalyst for Enantio-selective C-H Amination

Contributor(s): Hisashi Yamamoto, Marina Naodovic
D. N. Zalatan, J. Du Bois*
Stanford University, USA
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Publikationsdatum:
22. September 2008 (online)

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Significance

In this latest report, Du Bois’ group introduces a unique valerolactam-derived dirhodium catalyst for intramolecular C-H amination. This novel catalyst provides the highest levels of enantioselectivity observed for the transition-metal-catalyzed C-H amination of sulfamate esters. Another significant feature of this protocol is the high level of chemoselectivity observed for the homo­allyl sulfamate substrates.