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Synfacts 2008(10): 1099-1099
DOI: 10.1055/s-2008-1078150
DOI: 10.1055/s-2008-1078150
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Intermolecular Stetter Reaction by NHC Catalysis
D. Enders*, J. Han, A. Henseler
RWTH Aachen, Germany
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. September 2008 (online)
![](https://www.thieme-connect.de/media/synfacts/200810/lookinside/thumbnails/10.1055-s-2008-1078150-1.jpg)
Significance
The authors report the new N-benzyl-substituted triazolium salt 1 as N-heterocyclic carbene (NHC) precursor and its use in intermolecular, enantioselective Stetter reactions of aldehydes and chalcones. A kinetic study of the reaction showed rapid consumption of the aldehyde leading to benzoin condensation (BC) product 2. However, the Stetter reaction took place with high yields and good enantioselectivities (high ratios after recrystallization), because the initial BC (I) is reversible.