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Synfacts 2008(10): 1013-1013  
DOI: 10.1055/s-2008-1078186
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-Oocydin A

Contributor(s): Philip Kocienski
E. Roulland*
Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France
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Publication History

Publication Date:
22 September 2008 (online)

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Significance

(+)-Oocydin A was extracted from the bacterium Serratia marescens. Key steps in the synthesis depicted are (1) a Suzuki-Miyaura cross-coupling of the 1,1-dichloroalkene D with a 9-alkyl 9-BBN derivative derived from hydroboration of G and (2) the Pd(0)-catalyzed intramolecular O-allylation F → G.