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Synfacts 2008(10): 1111-1111  
DOI: 10.1055/s-2008-1078196
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Dehydrogenative Silylation of Primary Alcohols Catalyzed by [Au]-SMAP-Rh

Contributor(s): Yasuhiro Uozumi, Yutaka Matsuura
K. Hara*, R. Akiyama, S. Takakusagi, K. Uosaki, T. Yoshino, H. Kagi, M. Sawamura*
Hokkaido University, Sapporo and The University of Tokyo, Japan
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Publication History

Publication Date:
22 September 2008 (online)

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Significance

Immersion of the gold surface in a solution of phosphine 1 in EtOH afforded [Au]-SMAP 2. [Au]-SMAP 2 was treated with a solution of [RhCl(C2H4)2]2 in benzene to give [Au]-SMAP-Rh 3. ICP-MS measurement of 3 revealed that rhodium was incorporated at a concentration of 0.63 nmol/cm². [Au]-SMAP-Rh 3 was found to promote the dehydrogenative silylation of primary alcohols 4 to afford the corresponding silyl ether 5a-d with high TON up to 68,000 (eq. 1).