Cross-Coupling of Secondary Alkyltrifluoroborates with Aryl Chlorides

Significance

This valuable synthetic method demonstrates the usefulness of the parallel microscale experimentation approach in the development of new methodology in synthetic chemistry. Conditions for a smooth Pd-catalyzed cross-coupling between secondary alkyltrifluoroborates and aryl or heteroaryl chlorides have been found after the screening of a number of phosphine ligands. The parallel microscale experimentation is proved to be a very promising method of investigation in synthetic chemistry that will find more and more applications not only in industry, but also in the academic research.