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Synfacts 2008(10): 1086-1086
DOI: 10.1055/s-2008-1078223
DOI: 10.1055/s-2008-1078223
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
FeBr2-Catalyzed Synthesis of Benzimidazoles from Aryl Azides
M. Shen, T. G. Driver*
University of Illinois at Chicago, USA
Further Information
Publication History
Publication Date:
22 September 2008 (online)
Significance
This reaction represents the first example of the iron-catalyzed C-H amination by using azides, formerly known only with Rh catalysis. 2-Azidoanilines are readily available from 2-nitroanilines. The reaction gives high yields with most aryl aldehydes, tolerates important functional groups and can be useful for modular synthesis of benzimidazoles.