Amino Thioacetate Ligands for Enantioelective Aryl Transfers to Aldehydes

Significance

The development of chiral amino thioacetate ligands for the enantioselective aryl transfer to aldehydes is reported. In those reactions, the amino thioacetates are remarkably superior to the corresponding amino alcohols, probably because of the stronger affinity of sulfur toward the arylzinc species. Low catalyst loading (2.5-5 mol%) is sufficient to achive good yields in a short time with excellent enantioselectivities (up to 98% yield, up to 99% ee).