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Synfacts 2008(8): 0859-0859
DOI: 10.1055/s-2008-1078521
DOI: 10.1055/s-2008-1078521
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
A Highly Efficient Catalyst for Pd-Catalyzed Amination of Aryl Halides
Q. Sheng, T. Ogata, J. F. Hartwig*
Yale University, New Haven and University of Illinois, Urbana, USA
Further Information
Publication History
Publication Date:
23 July 2008 (online)
Significance
This article presents an extensive study on the selectivity, scope and structure-activity relations for the Pd-catalyzed amination of (het)aryl halides with primary amines. Aryl iodies, which are known to be more reluctant substrates to Pd-catalyzed amination, were also successfully converted.