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Synfacts 2008(8): 0858-0858  
DOI: 10.1055/s-2008-1078522
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Preparation of Methyl Ketones via Direct Coupling of Amides with CH2Cl2

Contributor(s): Paul Knochel, Tobias Thaler
K.-W. Lin, C.-H. Tsai, I.-L. Hsieh, T.-H. Yan*
National Chung-Hsing University, Taichung, Taiwan, P. R. of China
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Publication History

Publication Date:
23 July 2008 (online)

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Significance

A novel method for the preparation of methyl ketones from amides is described. Hereby, a highly nucleophilic titanium-methylene complex serves as methylenation reagent. The reaction is selective for amides and tolerates ester groups (CO2 t-Bu).