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Synfacts 2008(8): 0824-0824  
DOI: 10.1055/s-2008-1078581
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart ˙ New York

Selective Detection of Hypochlorous Acid

Contributor(s): Timothy M. Swager, Jan M. Schnorr
Z.-N. Sun, F.-Q. Liu, Y. Chen, P. K. H. Tam, D. Yang*
University of Hong Kong, P. R. of China
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Publication History

Publication Date:
23 July 2008 (online)

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Significance

The authors synthesized a ­BODIPY-based fluorescent probe for hypochlorous acid 9 from p-methoxyphenol 1 and pyrrole-2-carboxaldehyde 4. The fluorescence of 9 is quenched through a photo-electron-transfer (PET) process from the BODIPY to the p-methoxyphenyl moiety. Upon exposure to HOCl, 9 is transformed to its benzoquinoid analogue 10 in which no PET takes place resulting in a fluorescence response.