PDF herunterladen
Synfacts 2008(9): 0974-0974  
DOI: 10.1055/s-2008-1078622
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

1,3-Diketones via Rh-Catalyzed Reductive Acylation of Enones

Contributor(s): Paul Knochel, Andrey Gavryushin
K. Sato, S. Yamazoe, R. Yamamoto, S. Ohata, A. Tarui, M. Omote, I. Kamadaki, A. Ando*
Setsunan University, Osaka, Japan
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
22. August 2008 (online)

    Lizenzen und Reprints

Erratum zu diesem Artikel:

1,3-Diketones via Rh-Catalyzed Reductive Acylation of EnonesSynfacts 2008; 2008(10): 1123-1123
DOI: 10.1055/s-2008-1078048

Significance

1,3-Diketones are important synthetic intermediates, besides, some reveal useful biological activity. The direct Rh-catalyzed reductive acylation of enones solves the regioselectivity problem, encountered in conventional synthetic routes, and affords a simple approach to polysubstituted β-diketones, including polyarylated diketones. This is an interesting example of a selective α-functionalization of α,β-enones.