Mild Transesterification of Methyl Esters Catalyzed by a Zinc Cluster

Significance

A highly efficient, general catalytic method of transesterification of methyl esters is reported. The reaction occurs under relatively mild conditions. This method can be successfully applied to a variety of substrates, including enantio­pure aminoacids and oligopeptides. Most widely used protecting groups are not affected during this process. Acid-sensitive allylic alcohols like geraniol also react smoothly.