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Synfacts 2008(9): 0976-0976  
DOI: 10.1055/s-2008-1078628
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Directed Remote Metalation via N-Carbamoyl N Æ C Translocation

Contributor(s): Paul Knochel, Tobias Thaler
Z. Zhao, A. Jaworski, I. Piel, V. Snieckus*
Queen’s University, Kingston, Canada
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Publikationsdatum:
22. August 2008 (online)

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Significance

In this article a new directed remote metalation (DreM) concept is presented. Hereby, anionic N-carbamoyl migration was successfully used in the preparation of various 2-arylindoles. The carbamide functionality is directly and regio­selectively transferred to the respective aryl or vinyl moiety.