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Synfacts 2008(9): 0969-0969  
DOI: 10.1055/s-2008-1078632
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Highly Diastereoselective Ni-Catalyzed Reductive Aldol Cyclizations

Contributor(s): Paul Knochel, Tobias Thaler
P. M. Joensuu, G. J. Murray, E. A. F. Fordyce, T. Luebbers, H. W. Lam*
University of Edinburgh, UK and F. Hoffmann-La Roche Ltd., Basel, Switzerland
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Publication History

Publication Date:
22 August 2008 (online)

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Significance

This extensive study on Ni-catalyzed reductive aldol cyclizations with α,β-unsaturated amides and esters gives an overview of the large scope of this diastereoselective reaction and includes an extensive investigation of the possible mechanistic pathways.