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Synfacts 2008(9): 0990-0990  
DOI: 10.1055/s-2008-1078672
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Truncated Cinchona Alkaloids

Contributor(s): Benjamin List, Frank Lay
E. P. Kündig*, A. E. Garcia, T. Lomberget, P. P. Garcia, P. Romanens
University of Geneva, Switzerland
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Publikationsdatum:
22. August 2008 (online)

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Significance

The authors report an enantioselective monobenzoylation of meso-1,2-diols catalyzed by truncated cinchona alkaloid 1. Catalyst 1 can be synthesized from quinine in four steps. Moderate to high yields and enantiomeric ratios are achieved with low catalyst loadings (2 mol%).