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Synfacts 2008(9): 0994-0994
DOI: 10.1055/s-2008-1078673
DOI: 10.1055/s-2008-1078673
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Enantioselective, Brønsted Acid Catalyzed Reaction Cascade
M. Rueping*, A. P. Antonchick
Johann Wolfgang Goethe-University Frankfurt am Main, Germany
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. August 2008 (online)
Significance
A new enantioselective Brønsted acid catalyzed multiple-reaction cascade is reported. Each step is catalyzed by the same chiral phosphate 1. Various tetrahydropyridines and azadecalinones with different aromatic and aliphatic substituents were obtained in good yields with high enantioselectivities (er up to 99.5:0.5). The constitution and the absolute configuration were determined by X-ray crystal structure analysis.