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Thromb Haemost 2005; 93(03): 411-413
DOI: 10.1160/TH04-11-0715
DOI: 10.1160/TH04-11-0715
Rapid and Short Communication
Protein Z and protein Z-dependent protease inhibitor
Determinants of levels and risk of venous thrombosisFinancial support: This work was supported in part by grants from the National Institutes of Health (HL60782) and the Netherlands Heart Foundation (89.063).Further Information
Publication History
Received
04 November 2004
Accepted after revision
28 February 2004
Publication Date:
14 December 2017 (online)
Summary
To assess the potential roles of protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in venous thrombosis, their plasma levels were measured in 426 individuals with venous thrombosis and 471 control individuals participating in the Leiden Thrombophilia Study. A relationship between the level of PZ or ZPI and venous thrombosis was not detected in the overall case-control study. PZ and ZPI circulate as a complex and their plasma levels are interdependent. Both PZ and ZPI are increased with oral contraceptive use and reduced with oral anticoagulant therapy.
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