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CC BY-NC-ND 4.0 · Asian J Neurosurg 2021; 16(01): 208-211
DOI: 10.4103/ajns.AJNS_480_20
Case Report

Primary intraosseous xanthogranuloma in adult cervical spine: A case report of benign cause of lytic bone lesion

Sundus Ali
Department of Neurosurgery, King Edward Medical University/Mayo Hospital, Lahore
,
Adnan Qasim
Department of Neurosurgery, King Edward Medical University/Mayo Hospital, Lahore
,
Muhammad Sarwar
Department of Neurosurgery, King Edward Medical University/Mayo Hospital, Lahore
,
Attah Munam
Department of Neurosurgery, King Edward Medical University/Mayo Hospital, Lahore
,
Shahzad Shams
Department of Neurosurgery, King Edward Medical University/Mayo Hospital, Lahore
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Lytic lesions in adult spine are a common manifestation of aggressive disease such as primary bone tumor, metastasis, myeloma, or infectious pathology. Xanthoma arising in the spine with purely intraosseous component is an extremely rare occurrence with only six cases reported in the adult population, none in the cervical region. We report the first case of primary xanthoma of the cervical spine in a 50-year-old male solely confined to osseous compartment. The imaging mimics of lytic lesion with expansile mass in adult spine are reiterated.

Key-words:

Adult - bone xanthoma - cervical - lytic - spine

Financial support and sponsorship

Nil.




Publication History

Received: 24 October 2020

Accepted: 28 December 2020

Article published online:
16 August 2022

© 2021. Asian Congress of Neurological Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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  • References

  • 1 Alhaneedi G, Salameh M, Abu Hejleh H. Xanthoma of bone: A mini review. Arch Surg Oncol 2018;4:130. [Doi: 10.4172/2471-2671.1000130].
  • 2 Cao D, Ma J, Yang X, Xiao J. Solitary juvenile xanthogranuloma in the upper cervical spine: Case report and review of the literatures. Eur Spine J 2008;17:S318-23.
  • 3 Lee SJ, Jo DJ, Lee SH, Kim SM. Solitary xanthogranuloma of the upper cervical spine in a male adult. J Korean Neurosurg Soc 2012;51:54-8.
  • 4 Purohit D, Chanduka AK, Sharma V, Mittal RS, Singhvi S. Juvenile xanthogranuloma of adult spine: A rare case and review of literature. Asian J Neurosurg 2014;9:239.
  • 5 Oyama H, Ikeda K, Inoue S, Katsumata T, Murakami S, Doi A. A case of intradural xanthogranuloma in the upper cervical spine. Neurol Surg 1997;25:745-8.
  • 6 Inoue H, Seichi A, Yamamuro K, Kojima M, Kimura A, Hoshino Y. Dumbbell-type juvenile xanthogranuloma in the cervical spine of an adult. Eur Spine J 2011;20:S343-7.
  • 7 Konar S, Pandey P, Yasha TC. Solitary juvenile xanthogranuloma in cervical spine: Case report and review of the literature. Turk Neurosurg 2014;24:102-7.
  • 8 Pirillo V, Prontera A, Rizzo P, Cecchi PC, Maffei M, Schwarz A. A rare case of intramedullary solitary juvenile xanthogranuloma of the lumbar spine in the adult: A case report. J Spine Surg 2017;3:504-8.
  • 9 Robertson DP, Langford LA, McCutcheon IE. Primary xanthoma of thoracic spine presenting with myelopathy. Spine (Phila Pa 1976) 1995;20:1933-7.
  • 10 Chung JY, Moon ES, Song EK, Yoon TR, Jung ST, Bae BS, et al. Primary xanthoma of the lumbosacral spine a case report. J Musculoskelet Res 1999;3:167-73.
  • 11 Huang GS, Huang CW, Lee CH, Taylor JA, Lin CG, Chen CY, et al. Xanthoma of the sacrum. Skeletal Radiol 2004;33:674-8.
  • 12 Jain A, Mathur K, Khatri S, Kasana S, Jain SK. Rare presentation of juvenile xanthogranuloma in the thoracic spine of an adult patient: Case report and literature review. Acta Neurochir 2011;153:1813-8.
  • 13 Agabegi SS, Iorio TE, Wilson JD, Fischgrund JS. Juvenile xanthogranuloma in an adult lumbar spine: A case report. Spine (Phila Pa 1976) 2011;36:69-73.
  • 14 McLoughlin E, Iqbal A, Clamp J, Davies M, James S, Botchu R, et al. Xanthoma of the thoracic spine: A case report and review of literature. Indian J Musculoskelet Radiol 2019;1:68-71.
  • 15 Rampini PM, Alimehmeti RH, Egidi MG, Zavanone ML, Bauer D, Fossali E, et al. Isolated cervical juvenile xanthogranuloma in childhood. Spine 2001;26:1392-5.
  • 16 Bhaisora K, Jaiswal A, Mehrotra A, Sahu RN, Srivastava A, Jaiswal S, et al. Solitary juvenile xanthogranuloma of the cervical spine in a child: A case report and review of literature. Asian J Neurosurg 2015;10:57.
  • 17 Bertoni F, Unni KK, McLeod RA, Sim FH. Xanthoma of Bone. Am J Clin Pathol 1988;90:377-84.
  • 18 Dallari D, Marinelli A, Pellacani A, Valeriani L, Lesi C, Bertoni F, et al. Xanthoma of bone: First sign of hyperlipidemia type IIB: A case report. Clin Orthop Relat Res 2003;274-7.
  • 19 Dehner LP. Juvenile xanthogranulomas in the first two decades of life: A clinicopathologic study of 174 cases with cutaneous and extracutaneous manifestations. Am J Surg Pathol 2003;27:579-93.
  • 20 Abdel Razek AA, Castillo M. Imaging appearance of primary bony tumors and pseudo-tumors of the spine. J Neuroradiol 2010;37:37-50.
  • 21 Kim YS, Han IH, Lee IS, Lee JS, Choi BK. Imaging findings of solitary spinal bony lesions and the differential diagnosis of benign and malignant lesions. J Korean Neurosurg Soc 2012;52:126-32.
  • 22 Alden KJ, McCarthy EF, Weber KL. Xanthoma of bone: A report of three cases and review of the literature. Iowa Orthop J 2008;28:58-64.
  • 23 Margins in Spine Tumor Resection: How Much Is Enough? Is Planned Transgression Okay? | Musculoskeletal Key, Available from: https://musculoskeletalkey.com/margins-in-spine-tumor-resection-how-much-is-enough-is-planned-transgression-okay/. [Last accessed on 2020 Nov 24].
  • 24 Boriani S, Bandiera S, Donthineni R, Amendola L, Cappuccio M, De Iure F, et al. Morbidity of en bloc resections in the spine. Eur Spine J 2010;19:231-41.