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Synlett 2021; 32(16): 1625-1628
DOI: 10.1055/a-1328-0352
DOI: 10.1055/a-1328-0352
cluster
Modern Nickel-Catalyzed Reactions
Zn-Mediated Hydrodeoxygenation of Tertiary Alkyl Oxalates
This work was supported by the National Natural Science Foundation of China (grants 21871173 and 21572140).
Abstract
Herein we describe a general, mild, and scalable method for hydrodeoxygenation of readily accessible tertiary alkyl oxalates by Zn/silane under Ni-catalyzed conditions. The reduction method is suitable for an array of structural motifs derived from tertiary alcohols that bear diverse functional groups, including the synthesis of a key intermediate en route to estrone.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1328-0352.
- Supporting Information
Publication History
Received: 29 October 2020
Accepted after revision: 02 December 2020
Accepted Manuscript online:
02 December 2020
Article published online:
07 January 2021
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For reviews on aryl–O couplings, see:
For more examples on reductive formation of all-carbon quaternary centers, see:
For reviews on cross-electrophile couplings, see: