Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000134.xml
Diabetologie und Stoffwechsel 2021; 16(05): 372-375
DOI: 10.1055/a-1473-5028
DOI: 10.1055/a-1473-5028
Aktuell diskutiert
Einzeitiges Screening auf Gestationsdiabetes – Pro

Definition und Bedeutung des Gestationsdiabetes für Mutter und Kind
Der Gestationsdiabetes mellitus (GDM) ist eine Glukosetoleranzstörung, die in der Schwangerschaft auftritt. Der GDM ist Ausdruck einer mangelnden Anpassung des Stoffwechsels an die Veränderungen in der Schwangerschaft, die mit einer erheblichen Steigerung des Insulinbedarfes einhergehen [1]. Der Insulinbedarf steigt in der zweiten Hälfte der Schwangerschaft kontinuierlich an. Bei gesunden Frauen erfolgt kompensatorisch eine Steigerung der Insulinproduktion, die sich bis zum dritten Trimester verdoppelt [1]. Der Glukosestoffwechsel bleibt ausgeglichen und die Blutglukosewerte normal.
Publication History
Article published online:
18 October 2021
© 2021. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany
-
Literatur
- 1 Newbern D, Freemark M. Newbern & Freemark: Placental hormones and the control of maternal metabolism and fetal growth. Curr Opin Endocrinol Diabetes Obes 2011; 18 (06) 409-416
- 2 Desoye G, van Poppel M. The Feto-placental Dialogue in Diabesity. Best Practice & Research Clinical Obstetrics and Gynecology 2015;
- 3 Silverman BL, Metzger BE, Cho NH. et al. Impaired glucose tolerance in adolescent offspring of diabetic mothers. Relationship to fetal hyperinsulinism. Diabetes Care 1995; 18 (05) 611-617
- 4 Gluckman PD, Hanson MA, Cooper C. et al. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med 2008; 359 (01) 61-73
- 5 Gluckman PD, Hanson MA, Beedle AS. et al. Fetal and neonatal pathways to obesity. Front Horm Res 2008; 36: 61-72
- 6 Weschenfelder F, Hein F, Lehmann T. et al. Contributing Factors to Perinatal Outcome in Pregnancies with Gestational Diabetes-What Matters Most? A Retrospective Analysis. J Clin Med 18.01.2021;
- 7 Prutsky GJ, Domecq JP, Wang Z. et al. Glucose targets in pregnant women with diabetes: a systematic review and meta-analysis. J Clin Endocrinol Metab 2013; 98
- 8 Landon MB, Spong CY, Thom E. et al. Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network: A multicenter, randomized trial of treatment for mild gestational diabetes. N Engl J Med 01.10.2009; 361 (14)
- 9 Crowther CA, Alsweiler JM, Hughes R. et al. Target Study Group: Tight or less tight glycaemic targets for women with gestational diabetes mellitus for reducing maternal and perinatal morbidity? (TARGET): study protocol for a stepped wedge randomised trial. BMC Pregnancy Childbirth 2018;
- 10 The HAPO Study Cooperative Research Group. Hyperglycemia and Adverse Pregnancy Outcomes. N Engl J Med 2008; 358: 1991-2002
- 11 Cetin M, Cetin A. Time-dependent gestational diabetes screening values. Int J Gynaecol Obstet 1997; 56: 257-261
- 12 International Association of Diabetes and Pregnancy Study Groups Consensus Panel. International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care 2010; 33 (03) 676-682
- 13 Lewis GF, McNally C, Blackman JD. et al. Prior feeding alters the response to the 50-g glucose challenge test in pregnancy. The Staub-Traugott effect revisited. Diabetes Care 1993; 16: 1551-1556
- 14 Benhalima K, Minschart C, Ceulemans D. et al. Screening and Management of Gestational Diabetes Mellitus after Bariatric Surgery. Nutrients 2018; 10
- 15 Benhalima K, Van Crombrugge P, Moyson C. et al. The Sensitivity and Specificity of the Glucose Challenge Test in a Universal Two-Step Screening Strategy for Gestational Diabetes Mellitus Using the 2013 World Health Organization Criteria. Diabetes Care 2018; 41: e111-e112
- 16 Hillier TA, Pedula KL, Ogasawara KK. et al. A Pragmatic, Randomized Clinical Trial of Gestational Diabetes Screening. N Engl J Med 11.03.2021; 384 (10) 895-904