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Z Gastroenterol 2023; 61(02): 164-171
DOI: 10.1055/a-1797-2688
Originalarbeit

Validation of the German Inflammatory Bowel Disease Fatigue (IBD-F) Questionnaire

Erster validierter deutschsprachiger Fatigue-Fragebogen für PatientInnen mit chronisch-entzündlichen Darmerkrankungen (CED)
Karina Antonia Magdalena Scholz 
1   Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Magdeburg, Magdeburg, Germany (Ringgold ID: RIN39067)
,
Anne Kerstin Thomann 
2   Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
,
Niels Teich 
3   Internal medicine practice for Digestive and Metabolic Diseases, Leipzig, Germany
,
Hartmut Baumann
4   Gastroenterological practice Gardelegen, Gardelegen, Germany
,
Jens Walldorf
5   Department of Internal Medicine I, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany (Ringgold ID: RIN9176)
,
Carsten Büning
6   Department of Internal Medicine, Hospital Waldfriede, Berlin-Zehlendorf, Germany (Ringgold ID: RIN169360)
,
Rosa Rosania
1   Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Magdeburg, Magdeburg, Germany (Ringgold ID: RIN39067)
,
Ali Canbay
7   Department of Medicine, Knappschaftskrankenhaus, Ruhr University Bochum, Bochum, Germany (Ringgold ID: RIN9142)
,
Ulrike von Arnim
1   Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Magdeburg, Magdeburg, Germany (Ringgold ID: RIN39067)
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Abstract

Introduction Fatigue is a common symptom in patients with inflammatory bowel diseases (IBD). To date, there is no instrument to assess IBD-specific fatigue in German. The aim of this study was to translate the IBD Fatigue (IBD-F) scale and to test its psychometric properties in a German IBD population.

Methods After completing the translation process, 20 IBD patients participated in a pilot testing phase. For further analyses, 180 IBD patients with fatigue answered the IBD-F (Sections I, II, III) and the IBD Questionnaire (IBDQ-D). Reliability was tested by using Cronbach's alpha and corrected item–total correlation. Exploratory factor analyses (EFA) were carried out. Spearman’s correlation was calculated between the IBD-F and IBDQ-D . 78 patients could be included to calculate the test–retest reliability.

Results The German version of the IBD-F shows high face and content validity. Internal consistency was excellent, with a Cronbach's alpha of 0.93–0.98. Corrected item–total correlations ranged from 0.51 to 0.89. The correlation between the IBD-F and the IBDQ-D was statistically significant for Section I (rs=-0.59; p<0.01) and Section II (rs=-0.76; p<0.01) of the IBD-F. The EFA identified one relevant factor for each section. Test-retest reliability was acceptable for Section I (intraclass correlation coefficient (ICC)=0.73) and Section II (ICC=0.84).

Conclusion The German version of the IBD-F is a reliable and valid tool to assess fatigue in IBD.

Zusammenfassung

Einleitung Fatigue ist ein häufiges Symptom bei chronisch-entzündlichen Darmerkrankungen (CED). Derzeit existiert kein geeignetes deutschsprachiges Instrument zur Erfassung von Fatigue bei CED. Ziel ist es, den Inflammatory Bowel Disease Fatigue (IBD-F)-Fragebogen zu übersetzen und die Gütekriterien an einer deutschsprachigen Stichprobe zu validieren.

Methodik Nach Übersetzung des IBD-F nahmen 20 PatientInnen an einer Probetestung teil. Für weitere Analysen beantworteten 180 CED-PatientInnen mit Fatigue den IBD-F (Teil I, II, III) und den Inflammatory Bowel Disease Questionnaire (IBDQ-D). Die Reliabilität wurde mithilfe von Cronbachs α und Trennschärfen ermittelt. Explorative Faktorenanalysen (EFA) wurden durchgeführt. Die Korrelationen von IBD-F und IBDQ-D wurden evaluiert. 78 PatientInnen wurden zur Berechnung der Test-Retest-Reliabilität eingeschlossen.

Ergebnisse Die deutsche Version des IBD-F hat eine hohe Inhalts- und Augenscheinvalidität. Die interne Konsistenz war exzellent (Cronbachs α = 0.93–0.98). Die Trennschärfekoeffizienten lagen zwischen 0.51 und 0.89. Die Korrelationen zwischen IBD-F und IBDQ-D waren statistisch signifikant für Teil I (rs=-0.59; p<0.01) und Teil II (rs=-0.76; p<0.01) des IBD-F. Die einfaktorielle Struktur konnte für beide Teile bestätigt werden. Die Test-Retest-Reliabilität kann für Teil I (Intraklassenkorrelationskoeffizient (ICC)=0.73) und Teil II (ICC=0.84) als akzeptabel bewertet werden.

Schlussfolgerung Die deutsche Version des IBD-F ist ein zuverlässiges und valides Instrument zur Erfassung von Fatigue bei CED.

Schlüsselwörter

chronisch entzündliche Darmerkrankung - IBD - Fatigue - Validierung - Fragebogen

Keywords

Inflammatory Bowel Disease - IBD - Fatigue - Validation - Questionnaire

Supporting information



Publication History

Received: 03 December 2021

Accepted after revision: 11 March 2022

Article published online:
09 May 2022

© 2022. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 

  • References

  • 1 Burisch J, Jess T, Martinato M. et al. The burden of inflammatory bowel disease in Europe. J Crohns Colitis 2013; 7: 322-337
    CrossrefPubMedSearch in Google Scholar
  • 2 Keyashian K, Dehghan M, Sceats L. et al. Comparative Incidence of Inflammatory Bowel Disease in Different Age Groups in the United States. Inflamm Bowel Dis 2019; 25: 1983-1989
    CrossrefPubMedSearch in Google Scholar
  • 3 Viazis N, Mantzaris G, Karmiris K. et al. Inflammatory bowel disease: Greek patients’ perspective on quality of life, information on the disease, work productivity and family support. Ann Gastroenterol 2013; 26: 52-58
    PubMedSearch in Google Scholar
  • 4 Kemp K, Griffiths J, Lovell K. Understanding the health and social care needs of people living with IBD: a meta-synthesis of the evidence. World J Gastroenterol 2012; 18: 6240-6249
    CrossrefPubMedSearch in Google Scholar
  • 5 Singh S, Blanchard A, Walker JR. et al. Common symptoms and stressors among individuals with inflammatory bowel diseases. Clin Gastroenterol Hepatol 2011; 9: 769-775
    CrossrefPubMedSearch in Google Scholar
  • 6 Czuber-Dochan W, Norton C, Bassett P. et al. Development and psychometric testing of inflammatory bowel disease fatigue (IBD-F) patient self-assessment scale. J Crohns Colitis 2014; 8: 1398-1406
    CrossrefPubMedSearch in Google Scholar
  • 7 Borren NZ, van der Woude CJ, Ananthakrishnan AN. Fatigue in IBD: epidemiology, pathophysiology and management. Nat Rev Gastroenterol Hepatol 2019; 16: 247-259
    CrossrefPubMedSearch in Google Scholar
  • 8 Langenberg DR, Gibson PR. Systematic review: fatigue in inflammatory bowel disease. Aliment Pharmacol Ther 2010; 32: 131-143
    CrossrefPubMedSearch in Google Scholar
  • 9 Graff LA, Vincent N, Walker JR. et al. A population-based study of fatigue and sleep difficulties in inflammatory bowel disease. Inflamm Bowel Dis 2011; 17: 1882-1889
    CrossrefPubMedSearch in Google Scholar
  • 10 Cohen BL, Zoëga H, Shah SA. et al. Fatigue is highly associated with poor health-related quality of life, disability and depression in newly-diagnosed patients with inflammatory bowel disease, independent of disease activity. Aliment Pharmacol Ther 2014; 39: 811-822
    CrossrefPubMedSearch in Google Scholar
  • 11 Villoria A, García V, Dosal A. et al. Fatigue in out-patients with inflammatory bowel disease: Prevalence and predictive factors. PLoS ONE 2017; 12: e0181435
    CrossrefPubMedSearch in Google Scholar
  • 12 Jewanski V, Hoyer H, Ziegler J. et al. Fatigue bei Patienten mit chronisch entzündlichen Darmerkrankungen (CED): häufig und durch Laboruntersuchungen nicht zu erkennen! In: 74. Jahrestagung der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten mit Sektion Endoskopie – 13. Herbsttagung der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie gemeinsam mit den Arbeitsgemeinschaften der DGAV. Zeitschrift für Gastroenterologie. Georg Thieme Verlag KG; 2019.
    Thieme ConnectSearch in Google Scholar
  • 13 Jonefjäll B, Simrén M, Lasson A. et al. Psychological distress, iron deficiency, active disease and female gender are independent risk factors for fatigue in patients with ulcerative colitis. United European Gastroenterol J 2018; 6: 148-158
    CrossrefPubMedSearch in Google Scholar
  • 14 Gennep S, Evers SW, Rietdijk ST. et al. High Disease Burden Drives Indirect Costs in Employed Inflammatory Bowel Disease Patients: The WORK-IBD Study. Inflamm Bowel Dis 2020;
    CrossrefPubMedSearch in Google Scholar
  • 15 Jelsness-Jørgensen L-P, Bernklev T, Henriksen M. et al. Chronic fatigue is more prevalent in patients with inflammatory bowel disease than in healthy controls. Inflamm Bowel Dis 2011; 17: 1564-1572
    CrossrefPubMedSearch in Google Scholar
  • 16 Liebert A, Gawron-Kiszka M, Budzyńska A. et al. P175 Fatigue and its severity depends on demographic and clinical factors in the Polish population of patients with inflammatory bowel disease – results of a cross-sectional study. Journal of Crohn’s and Colitis 2018; 12: S186-S186
    CrossrefPubMedSearch in Google Scholar
  • 17 Goldenberg BA, Graff LA, Clara I. et al. Is iron deficiency in the absence of anemia associated with fatigue in inflammatory bowel disease?. Am J Gastroenterol 2013; 108: 1392-1397
    CrossrefPubMedSearch in Google Scholar
  • 18 Bager P, Befrits R, Wikman O. et al. Fatigue in out-patients with inflammatory bowel disease is common and multifactorial. Aliment Pharmacol Ther 2012; 35: 133-141
    CrossrefPubMedSearch in Google Scholar
  • 19 Frigstad SO, Høivik ML, Jahnsen J. et al. Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients. World J Gastroenterol 2018; 24: 3293-3301
    CrossrefPubMedSearch in Google Scholar
  • 20 Kucharzik T, Dignass AU, Atreya R. et al. Aktualisierte S3-Leitlinie Colitis ulcerosa – Living Guideline. Z Gastroenterol 2020; 58: e241-e326
    Thieme ConnectPubMedSearch in Google Scholar
  • 21 Sturm A, Atreya R, Bettenworth D. et al. Aktualisierte S3-Leitlinie „Diagnostik und Therapie des Morbus Crohn“ der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS). 021. Aufl. AWMF online. 2021
    PubMedSearch in Google Scholar
  • 22 Czuber-Dochan W, Ream E, Norton C. Review article: Description and management of fatigue in inflammatory bowel disease. Aliment Pharmacol Ther 2013; 37: 505-516
    CrossrefPubMedSearch in Google Scholar
  • 23 Czuber-Dochan W, Dibley LB, Terry H. et al. The experience of fatigue in people with inflammatory bowel disease: an exploratory study. J Adv Nurs 2013; 69: 1987-1999
    CrossrefPubMedSearch in Google Scholar
  • 24 Janke K-H, Steder-Neukamm U, Bauer M. et al. Lebensqualität bei chronisch entzündlichen Darmerkrankungen (CED): die deutsche Version des Inflammatory Bowel Disease Questionnaire (IBDQ-D) zur krankheitsspezifischen Lebensqualitätsmessung -- erste Anwendung und Vergleich mit anderen internationalen Fassungen. Gesundheitswesen 2005; 67: 656-664
    Thieme ConnectPubMedSearch in Google Scholar
  • 25 Janke K-H, Klump B, Steder-Neukamm U. et al. Validierung der Deutschen Version (Kompetenznetz „Chronisch entzündliche Darmerkrankungen”) des Inflammatory Bowel Disease Questionnaire IBDQ-D. Psychother Psych Med 2006; 56: 291-298
    Thieme ConnectPubMedSearch in Google Scholar
  • 26 Harvey RF, Bradshaw JM. A Simple index of Crohn’s-disease activity. The Lancet 1980; 315: 514
    CrossrefPubMedSearch in Google Scholar
  • 27 Lewis JD, Chuai S, Nessel L. et al. Use of the noninvasive components of the Mayo score to assess clinical response in ulcerative colitis. Inflamm Bowel Dis 2008; 14: 1660-1666
    CrossrefPubMedSearch in Google Scholar
  • 28 Peyrin-Biroulet L, Panés J, Sandborn WJ. et al. Defining Disease Severity in Inflammatory Bowel Diseases: Current and Future Directions. Clin Gastroenterol Hepatol 2016; 14: 348-354.e17
    CrossrefPubMedSearch in Google Scholar
  • 29 Nunnally JC. Psychometric theory. McGraw-Hill series in psychology. 2nd ed.. New York: McGraw-Hill; 1978
    Search in Google Scholar
  • 30 Holcomb ZC, Cox KS. Interpreting Basic Statistics: A Workbook Based on Excerpts from Journal Articles. 8th ed.. Milton: Taylor and Francis; 2017
    CrossrefSearch in Google Scholar
  • 31 Terwee CB, Bot SDM, de Boer MR. et al. Quality criteria were proposed for measurement properties of health status questionnaires. J Clin Epidemiol 2007; 60: 34-42
    CrossrefPubMedSearch in Google Scholar
  • 32 Kline P. A psychometrics primer. London: Free Association; 2000
    Search in Google Scholar
  • 33 Lage AC, Oliveira CC, Batalha APDB. et al. The inflammatory bowel disease-fatigue patient self-assessment scale: translation, cross-cultural adaptation and psychometric properties of the brazilian version (IBD-F Brazil). Arq Gastroenterol 2020; 57: 50-63
    CrossrefPubMedSearch in Google Scholar
  • 34 Vestergaard C, Dahlerup JF, Bager P. Validation of the Danish version of Inflammatory Bowel Disease Self-assessment Scale. Dan Med J 2017; 64: A5394-A5394
    PubMedSearch in Google Scholar
  • 35 Keightley P, Reay RE, Pavli P. et al. Inflammatory bowel disease-related fatigue is correlated with depression and gender. Australas Psychiatry 2018; 26: 508-513
    CrossrefPubMedSearch in Google Scholar
  • 36 Fatigue in IBD. Accessed August 17, 2020 at: http://www.fatigueinibd.co.uk/questionnaire/
    PubMed