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Synlett 2022; 33(10): 969-972
DOI: 10.1055/a-1804-7546
DOI: 10.1055/a-1804-7546
letter
Rh(III)-Catalyzed Synthesis of 2-Nitro-2H-azirines via sp3 C–H Activation
The authors gratefully acknowledge funding from Jiangsu Students’ Platform for Innovation and Entrepreneurship Training Program and the Starting Funding of Research from Nanjing Tech University.
Abstract
An expedient Rh(III)-catalytic method has been described to synthesis of 2-nitro-2H-azirine derivatives from easily accessible β-nitrooxime ethers via sp3 C–H activation process. This protocol features of low catalyst loading, very mild reaction conditions, and tolerating a diverse of functionalities in good yields. A possible reaction pathway is proposed involving [RhCp*Cl2]2-catalyzed sp3 C–H bond activation and pivalic acid elimination steps.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1804-7546.
- Supporting Information
Publication History
Received: 14 February 2022
Accepted after revision: 22 March 2022
Accepted Manuscript online:
22 March 2022
Article published online:
10 May 2022
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