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Semin Neurol 2022; 42(05): 639-657
DOI: 10.1055/a-1958-0710
Review Article

Sleep Disturbances in Neurological Disease: A Target for Intervention

Seva G. Khambadkone
1   Department of Pediatrics, Oregon Health & Science University, Portland, Oregon
,
Sara E. Benjamin
2   Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland
3   Johns Hopkins Center for Sleep, Columbia, Maryland
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Abstract

Sleep is a biological function required for neurological and general health, but a significant and under-recognized proportion of the population has disturbed sleep. Here, we briefly overview the biology of sleep, sleep requirements over the lifespan, and common sleep disorders. We then turn our attention to five neurological diseases that significantly contribute to global disease burden and neurology practice makeup: epilepsy, headache, ischemic stroke, Parkinson's disease, and Alzheimer's disease. For each disease, we review evidence that sleep disturbances contribute to disease risk and severity and discuss existing data that addressing sleep disturbances may have disease-modifying effects. We provide recommendations derived from the literature and existing clinical guidelines to facilitate the evaluation and management of sleep disturbances within the context of each neurological disease. Finally, we synthesize identified needs and commonalities into future directions for the field and practical sleep-related recommendations for physicians caring for patients at risk for or currently suffering from neurological disease.

Keywords

sleep - sleep apnea - insomnia - epilepsy - headache - stroke - Parkinson's disease - Alzheimer's disease


Publication History

Accepted Manuscript online:
10 October 2022

Article published online:
13 December 2022

© 2022. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

  • References

  • 1 Horner RL, Peever JH. Brain circuitry controlling sleep and wakefulness. Continuum (Minneap Minn) 2017; 23 (4, Sleep Neurology): 955-972
    PubMedGoogle Scholar
  • 2 Agostini A, Centofanti S. Normal sleep in children and adolescence. Child Adolesc Psychiatr Clin N Am 2021; 30 (01) 1-14
    CrossrefPubMedGoogle Scholar
  • 3 Ohayon MM, Carskadon MA, Guilleminault C, Vitiello MV. Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan. Sleep 2004; 27 (07) 1255-1273
    CrossrefPubMedGoogle Scholar
  • 4 Danker-Hopfe H. Growth and development of children with a special focus on sleep. Prog Biophys Mol Biol 2011; 107 (03) 333-338
    CrossrefPubMedGoogle Scholar
  • 5 Medic G, Wille M, Hemels ME. Short- and long-term health consequences of sleep disruption. Nat Sci Sleep 2017; 9: 151-161
    CrossrefPubMedGoogle Scholar
  • 6 Tefft BC. Prevalence of motor vehicle crashes involving drowsy drivers, United States, 1999-2008. Accid Anal Prev 2012; 45: 180-186
    CrossrefPubMedGoogle Scholar
  • 7 Schutte-Rodin S, Broch L, Buysse D, Dorsey C, Sateia M. Clinical guideline for the evaluation and management of chronic insomnia in adults. J Clin Sleep Med 2008; 4 (05) 487-504
    CrossrefPubMedGoogle Scholar
  • 8 Lin J, Suurna M. Sleep apnea and sleep-disordered breathing. Otolaryngol Clin North Am 2018; 51 (04) 827-833
    CrossrefPubMedGoogle Scholar
  • 9 Ralls F, Cutchen L. A contemporary review of obstructive sleep apnea. Curr Opin Pulm Med 2019; 25 (06) 578-593
    CrossrefPubMedGoogle Scholar
  • 10 Gamaldo C, Buenaver L, Chernyshev O. et al; OSA Assessment Tools Task Force of the American Academy of Sleep Medicine. Evaluation of clinical tools to screen and assess for obstructive sleep apnea. J Clin Sleep Med 2018; 14 (07) 1239-1244
    CrossrefPubMedGoogle Scholar
  • 11 Memon J, Manganaro SN. Obstructive Sleep-Disordered Breathing. StatPearls; 2022
    Google Scholar
  • 12 Eckert DJ, Jordan AS, Merchia P, Malhotra A. Central sleep apnea: pathophysiology and treatment. Chest 2007; 131 (02) 595-607
    CrossrefPubMedGoogle Scholar
  • 13 Aurora RN, Kristo DA, Bista SR. et al; American Academy of Sleep Medicine. The treatment of restless legs syndrome and periodic limb movement disorder in adults – an update for 2012: practice parameters with an evidence-based systematic review and meta-analyses: an American Academy of Sleep Medicine Clinical Practice Guideline. Sleep 2012; 35 (08) 1039-1062
    CrossrefPubMedGoogle Scholar
  • 14 Trenkwalder C, Allen R, Högl B. et al. Comorbidities, treatment, and pathophysiology in restless legs syndrome. Lancet Neurol 2018; 17 (11) 994-1005
    CrossrefPubMedGoogle Scholar
  • 15 Auger RR, Burgess HJ, Emens JS, Deriy LV, Thomas SM, Sharkey KM. Clinical practice guideline for the treatment of intrinsic circadian rhythm sleep-wake disorders: advanced sleep-wake phase disorder (ASWPD), delayed sleep-wake phase disorder (DSWPD), non-24-hour sleep-wake rhythm disorder (N24SWD), and irregular sleep-wake rhythm disorder (ISWRD). An update for 2015: an American Academy of Sleep Medicine Clinical Practice Guideline. J Clin Sleep Med 2015; 11 (10) 1199-1236
    Google Scholar
  • 16 Aurora RN, Zak RS, Maganti RK. et al; Standards of Practice Committee, American Academy of Sleep Medicine. Best practice guide for the treatment of REM sleep behavior disorder (RBD). J Clin Sleep Med 2010; 6 (01) 85-95
    CrossrefPubMedGoogle Scholar
  • 17 GBD 2016 Neurology Collaborators. Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 2019; 18 (05) 459-480
    Google Scholar
  • 18 Nobili L, de Weerd A, Rubboli G. et al. Standard procedures for the diagnostic pathway of sleep-related epilepsies and comorbid sleep disorders: an EAN, ESRS and ILAE-Europe consensus review. Eur J Neurol 2021; 28 (01) 15-32
    CrossrefPubMedGoogle Scholar
  • 19 Kataria L, Vaughn BV. Sleep and epilepsy. Sleep Med Clin 2016; 11 (01) 25-38
    CrossrefPubMedGoogle Scholar
  • 20 Nobili L, Beniczky S, Eriksson SH. et al. Expert opinion: managing sleep disturbances in people with epilepsy. Epilepsy Behav 2021; 124: 108341
    CrossrefPubMedGoogle Scholar
  • 21 Sveinsson O, Andersson T, Mattsson P, Carlsson S, Tomson T. Clinical risk factors in SUDEP: a nationwide population-based case-control study. Neurology 2020; 94 (04) e419-e429
    CrossrefPubMedGoogle Scholar
  • 22 Halász P, Bódizs R, Ujma PP, Fabó D, Szűcs A. Strong relationship between NREM sleep, epilepsy and plastic functions - a conceptual review on the neurophysiology background. Epilepsy Res 2019; 150: 95-105
    CrossrefPubMedGoogle Scholar
  • 23 Tononi G, Cirelli C. Sleep function and synaptic homeostasis. Sleep Med Rev 2006; 10 (01) 49-62
    CrossrefPubMedGoogle Scholar
  • 24 Diekelmann S, Born J. The memory function of sleep. Nat Rev Neurosci 2010; 11 (02) 114-126
    Google Scholar
  • 25 Aaberg KM, Bakken IJ, Lossius MI. et al. Comorbidity and childhood epilepsy: a nationwide registry study. Pediatrics 2016; 138 (03) e20160921
    CrossrefPubMedGoogle Scholar
  • 26 Byars AW, Byars KC, Johnson CS. et al. The relationship between sleep problems and neuropsychological functioning in children with first recognized seizures. Epilepsy Behav 2008; 13 (04) 607-613
    CrossrefPubMedGoogle Scholar
  • 27 Stores G, Wiggs L, Campling G. Sleep disorders and their relationship to psychological disturbance in children with epilepsy. Child Care Health Dev 1998; 24 (01) 5-19
    CrossrefPubMedGoogle Scholar
  • 28 Cortesi F, Giannotti F, Ottaviano S. Sleep problems and daytime behavior in childhood idiopathic epilepsy. Epilepsia 1999; 40 (11) 1557-1565
    CrossrefPubMedGoogle Scholar
  • 29 Becker DA, Fennell EB, Carney PR. Daytime behavior and sleep disturbance in childhood epilepsy. Epilepsy Behav 2004; 5 (05) 708-715
    CrossrefPubMedGoogle Scholar
  • 30 Ng M, Pavlova M. Why are seizures rare in rapid eye movement sleep? Review of the frequency of seizures in different sleep stages. Epilepsy Res Treat 2013; 2013: 932790
    PubMedGoogle Scholar
  • 31 Herman ST, Walczak TS, Bazil CW. Distribution of partial seizures during the sleep–wake cycle: differences by seizure onset site. Neurology 2001; 56 (11) 1453-1459
    CrossrefPubMedGoogle Scholar
  • 32 Basile C, Gigliotti F, Cesario S, Bruni O. The relation between sleep and neurocognitive development in infancy and early childhood: a neuroscience perspective. Adv Child Dev Behav 2021; 60: 9-27
    CrossrefPubMedGoogle Scholar
  • 33 Knoop MS, de Groot ER, Dudink J. Current ideas about the roles of rapid eye movement and non-rapid eye movement sleep in brain development. Acta Paediatr 2021; 110 (01) 36-44
    CrossrefPubMedGoogle Scholar
  • 34 Simor P, van der Wijk G, Nobili L, Peigneux P. The microstructure of REM sleep: Why phasic and tonic?. Sleep Med Rev 2020; 52: 101305
    CrossrefPubMedGoogle Scholar
  • 35 van Golde EG, Gutter T, de Weerd AW. Sleep disturbances in people with epilepsy; prevalence, impact and treatment. Sleep Med Rev 2011; 15 (06) 357-368
    CrossrefPubMedGoogle Scholar
  • 36 Khatami R, Zutter D, Siegel A, Mathis J, Donati F, Bassetti CL. Sleep-wake habits and disorders in a series of 100 adult epilepsy patients – a prospective study. Seizure 2006; 15 (05) 299-306
    CrossrefPubMedGoogle Scholar
  • 37 Sivathamboo S, Farrand S, Chen Z. et al. Sleep-disordered breathing among patients admitted for inpatient video-EEG monitoring. Neurology 2019; 92 (03) e194-e204
    CrossrefPubMedGoogle Scholar
  • 38 Maurousset A, De Toffol B, Praline J, Biberon J, Limousin N. High incidence of obstructive sleep apnea syndrome in patients with late-onset epilepsy. Neurophysiol Clin 2017; 47 (01) 55-61
    CrossrefPubMedGoogle Scholar
  • 39 McCarter AR, Timm PC, Shepard PW. et al. Obstructive sleep apnea in refractory epilepsy: a pilot study investigating frequency, clinical features, and association with risk of sudden unexpected death in epilepsy. Epilepsia 2018; 59 (10) 1973-1981
    CrossrefPubMedGoogle Scholar
  • 40 Malow BA, Levy K, Maturen K, Bowes R. Obstructive sleep apnea is common in medically refractory epilepsy patients. Neurology 2000; 55 (07) 1002-1007
    CrossrefPubMedGoogle Scholar
  • 41 Manni R, Terzaghi M, Arbasino C, Sartori I, Galimberti CA, Tartara A. Obstructive sleep apnea in a clinical series of adult epilepsy patients: frequency and features of the comorbidity. Epilepsia 2003; 44 (06) 836-840
    CrossrefPubMedGoogle Scholar
  • 42 Chihorek AM, Abou-Khalil B, Malow BA. Obstructive sleep apnea is associated with seizure occurrence in older adults with epilepsy. Neurology 2007; 69 (19) 1823-1827
    CrossrefPubMedGoogle Scholar
  • 43 Liu S, Yu W, Lü Y. The causes of new-onset epilepsy and seizures in the elderly. Neuropsychiatr Dis Treat 2016; 12: 1425-1434
    PubMedGoogle Scholar
  • 44 Bianchi MT, Cash SS, Mietus J, Peng CK, Thomas R. Obstructive sleep apnea alters sleep stage transition dynamics. PLoS One 2010; 5 (06) e11356
    CrossrefPubMedGoogle Scholar
  • 45 Perucca P, Dubeau F, Gotman J. Widespread EEG changes precede focal seizures. PLoS One 2013; 8 (11) e80972
    CrossrefPubMedGoogle Scholar
  • 46 Frauscher B, von Ellenrieder N, Ferrari-Marinho T, Avoli M, Dubeau F, Gotman J. Facilitation of epileptic activity during sleep is mediated by high amplitude slow waves. Brain 2015; 138 (Pt 6): 1629-1641
    CrossrefPubMedGoogle Scholar
  • 47 Sivathamboo S, Perucca P, Velakoulis D. et al. Sleep-disordered breathing in epilepsy: epidemiology, mechanisms, and treatment. Sleep 2018; 41 (04) DOI: 10.1093/sleep/zsy015.
    CrossrefPubMedGoogle Scholar
  • 48 Kaleyias J, Cruz M, Goraya JS. et al. Spectrum of polysomnographic abnormalities in children with epilepsy. Pediatr Neurol 2008; 39 (03) 170-176
    CrossrefPubMedGoogle Scholar
  • 49 Zanzmera P, Shukla G, Gupta A. et al. Markedly disturbed sleep in medically refractory compared to controlled epilepsy - a clinical and polysomnography study. Seizure 2012; 21 (07) 487-490
    CrossrefPubMedGoogle Scholar
  • 50 Touchon J, Baldy-Moulinier M, Billiard M, Besset A, Cadilhac J. Sleep organization and epilepsy. Epilepsy Res Suppl 1991; 2: 73-81
    PubMedGoogle Scholar
  • 51 Vendrame M, Auerbach S, Loddenkemper T, Kothare S, Montouris G. Effect of continuous positive airway pressure treatment on seizure control in patients with obstructive sleep apnea and epilepsy. Epilepsia 2011; 52 (11) e168-e171
    CrossrefPubMedGoogle Scholar
  • 52 Pornsriniyom D, Kim Hw, Bena J, Andrews ND, Moul D, Foldvary-Schaefer N. Effect of positive airway pressure therapy on seizure control in patients with epilepsy and obstructive sleep apnea. Epilepsy Behav 2014; 37: 270-275
    CrossrefPubMedGoogle Scholar
  • 53 Segal E, Vendrame M, Gregas M, Loddenkemper T, Kothare SV. Effect of treatment of obstructive sleep apnea on seizure outcomes in children with epilepsy. Pediatr Neurol 2012; 46 (06) 359-362
    CrossrefPubMedGoogle Scholar
  • 54 Yeh WC, Lu SR, Wu MN. et al. The impact of antiseizure medications on polysomnographic parameters: a systematic review and meta-analysis. Sleep Med 2021; 81: 319-326
    CrossrefPubMedGoogle Scholar
  • 55 Foldvary-Schaefer N, Andrews ND, Pornsriniyom D, Moul DE, Sun Z, Bena J. Sleep apnea and epilepsy: who's at risk?. Epilepsy Behav 2012; 25 (03) 363-367
    CrossrefPubMedGoogle Scholar
  • 56 Unterberger I, Gabelia D, Prieschl M. et al. Sleep disorders and circadian rhythm in epilepsy revisited: a prospective controlled study. Sleep Med 2015; 16 (02) 237-242
    CrossrefPubMedGoogle Scholar
  • 57 Stovner Lj, Hagen K, Jensen R. et al. The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia 2007; 27 (03) 193-210
    CrossrefPubMedGoogle Scholar
  • 58 Cho SJ, Song TJ, Chu MK. Sleep and tension-type headache. Curr Neurol Neurosci Rep 2019; 19 (07) 44
    CrossrefPubMedGoogle Scholar
  • 59 Yang CP, Wang SJ. Sleep in patients with chronic migraine. Curr Pain Headache Rep 2017; 21 (09) 39
    CrossrefPubMedGoogle Scholar
  • 60 Tiseo C, Vacca A, Felbush A. et al; European Headache Federation School of Advanced Studies (EHF-SAS). Migraine and sleep disorders: a systematic review. J Headache Pain 2020; 21 (01) 126
    CrossrefPubMedGoogle Scholar
  • 61 Rains JC, Poceta JS. Sleep-related headaches. Neurol Clin 2012; 30 (04) 1285-1298
    CrossrefPubMedGoogle Scholar
  • 62 Rains JC. Sleep and migraine: assessment and treatment of comorbid sleep disorders. Headache 2018; 58 (07) 1074-1091
    CrossrefPubMedGoogle Scholar
  • 63 Sullivan DP, Martin PR. Sleep and headaches: relationships between migraine and non-migraine headaches and sleep duration, sleep quality, chronotype, and obstructive sleep apnoea risk. Aust J Psychol 2017; 69 (03) 210-217 . Available at: https://doi.org/10.1111/ajpy.12143
    CrossrefPubMedGoogle Scholar
  • 64 Pellegrino ABW, Davis-Martin RE, Houle TT, Turner DP, Smitherman TA. Perceived triggers of primary headache disorders: a meta-analysis. Cephalalgia 2018; 38 (06) 1188-1198
    CrossrefPubMedGoogle Scholar
  • 65 Fernández-de-Las-Peñas C, Fernández-Muñoz JJ, Palacios-Ceña M, Parás-Bravo P, Cigarán-Méndez M, Navarro-Pardo E. Sleep disturbances in tension-type headache and migraine. Ther Adv Neurol Disord 2017; 11: 17 56285617745444
    PubMedGoogle Scholar
  • 66 Odegård SS, Sand T, Engstrøm M, Stovner LJ, Zwart J-A, Hagen K. The long-term effect of insomnia on primary headaches: a prospective population-based cohort study (HUNT-2 and HUNT-3). Headache 2011; 51 (04) 570-580
    CrossrefPubMedGoogle Scholar
  • 67 Ødegård SS, Sand T, Engstrøm M, Zwart J-A, Hagen K. The impact of headache and chronic musculoskeletal complaints on the risk of insomnia: longitudinal data from the Nord-Trøndelag health study. J Headache Pain 2013; 14 (01) 24
    CrossrefPubMedGoogle Scholar
  • 68 Martin PR, MacLeod C. Behavioral management of headache triggers: avoidance of triggers is an inadequate strategy. Clin Psychol Rev 2009; 29 (06) 483-495
    CrossrefPubMedGoogle Scholar
  • 69 Houle TT, Butschek RA, Turner DP, Smitherman TA, Rains JC, Penzien DB. Stress and sleep duration predict headache severity in chronic headache sufferers. Pain 2012; 153 (12) 2432-2440
    CrossrefPubMedGoogle Scholar
  • 70 Ong JC, Stepanski EJ, Gramling SE. Pain coping strategies for tension-type headache: possible implications for insomnia?. J Clin Sleep Med 2009; 5 (01) 52-56
    CrossrefPubMedGoogle Scholar
  • 71 Haque B, Rahman KM, Hoque A. et al. Precipitating and relieving factors of migraine versus tension type headache. BMC Neurol 2012; 12: 82
    CrossrefPubMedGoogle Scholar
  • 72 Kikuchi H, Yoshiuchi K, Yamamoto Y, Komaki G, Akabayashi A. Does sleep aggravate tension-type headache?: An investigation using computerized ecological momentary assessment and actigraphy. Biopsychosoc Med 2011; 5: 10
    CrossrefPubMedGoogle Scholar
  • 73 Gori S, Morelli N, Maestri M, Fabbrini M, Bonanni E, Murri L. Sleep quality, chronotypes and preferential timing of attacks in migraine without aura. J Headache Pain 2005; 6 (04) 258-260
    CrossrefPubMedGoogle Scholar
  • 74 Im HJ, Baek SH, Yun CH, Chu MK. Time preference of headache attack and chronotype in migraine and tension-type headache. Chronobiol Int 2019; 36 (11) 1528-1536
    CrossrefPubMedGoogle Scholar
  • 75 van Oosterhout W, van Someren E, Schoonman GG. et al. Chronotypes and circadian timing in migraine. Cephalalgia 2018; 38 (04) 617-625
    CrossrefPubMedGoogle Scholar
  • 76 Sullivan DP, Martin PR, Boschen MJ. Psychological sleep interventions for migraine and tension-type headache: a systematic review and meta-analysis. Sci Rep 2019; 9 (01) 6411
    CrossrefPubMedGoogle Scholar
  • 77 Ong JC, Park M. Chronic headaches and insomnia: working toward a biobehavioral model. Cephalalgia 2012; 32 (14) 1059-1070
    CrossrefPubMedGoogle Scholar
  • 78 Kallweit U, Hidalgo H, Uhl V, Sándor PS. Continuous positive airway pressure therapy is effective for migraines in sleep apnea syndrome. Neurology 2011; 76 (13) 1189-1191
    CrossrefPubMedGoogle Scholar
  • 79 Johnson KG, Ziemba AM, Garb JL. Improvement in headaches with continuous positive airway pressure for obstructive sleep apnea: a retrospective analysis. Headache 2013; 53 (02) 333-343
    CrossrefPubMedGoogle Scholar
  • 80 GBD 2019 Stroke Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol 2021; 20 (10) 795-820
    CrossrefPubMedGoogle Scholar
  • 81 Oza R, Rundell K, Garcellano M. Recurrent ischemic stroke: strategies for prevention. Am Fam Physician 2017; 96 (07) 436-440
    PubMedGoogle Scholar
  • 82 Kolmos M, Christoffersen L, Kruuse C. Recurrent ischemic stroke - a systematic review and meta-analysis. J Stroke Cerebrovasc Dis 2021; 30 (08) 105935
    CrossrefPubMedGoogle Scholar
  • 83 Koo DL, Nam H, Thomas RJ, Yun CH. Sleep disturbances as a risk factor for stroke. J Stroke 2018; 20 (01) 12-32
    CrossrefPubMedGoogle Scholar
  • 84 Parra O, Arboix A, Bechich S. et al. Time course of sleep-related breathing disorders in first-ever stroke or transient ischemic attack. Am J Respir Crit Care Med 2000; 161 (2, Pt 1): 375-380
    CrossrefPubMedGoogle Scholar
  • 85 Brown DL, Mowla A, McDermott M. et al. Ischemic stroke subtype and presence of sleep-disordered breathing: the BASIC sleep apnea study. J Stroke Cerebrovasc Dis 2015; 24 (02) 388-393
    CrossrefPubMedGoogle Scholar
  • 86 Fisse AL, Kemmling A, Teuber A. et al. The association of lesion location and sleep related breathing disorder in patients with acute ischemic stroke. PLoS One 2017; 12 (01) e0171243
    CrossrefPubMedGoogle Scholar
  • 87 Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med 2005; 353 (19) 2034-2041
    CrossrefPubMedGoogle Scholar
  • 88 Dong JY, Zhang YH, Qin LQ. Obstructive sleep apnea and cardiovascular risk: meta-analysis of prospective cohort studies. Atherosclerosis 2013; 229 (02) 489-495
    CrossrefPubMedGoogle Scholar
  • 89 Khot SP, Morgenstern LB. Sleep and stroke. Stroke 2019; 50 (06) 1612-1617
    CrossrefPubMedGoogle Scholar
  • 90 Nieto FJ, Young TB, Lind BK. et al. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA 2000; 283 (14) 1829-1836
    CrossrefPubMedGoogle Scholar
  • 91 Peppard PE, Young T, Palta M, Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 2000; 342 (19) 1378-1384
    CrossrefPubMedGoogle Scholar
  • 92 Reutrakul S, Mokhlesi B. Obstructive sleep apnea and diabetes: a state of the art review. Chest 2017; 152 (05) 1070-1086
    CrossrefPubMedGoogle Scholar
  • 93 Rasche K, Keller T, Tautz B. et al. Obstructive sleep apnea and type 2 diabetes. Eur J Med Res 2010; 15 (Suppl. 02) 152-156
    CrossrefPubMedGoogle Scholar
  • 94 Mehra R, Benjamin EJ, Shahar E. et al; Sleep Heart Health Study. Association of nocturnal arrhythmias with sleep-disordered breathing: the Sleep Heart Health Study. Am J Respir Crit Care Med 2006; 173 (08) 910-916
    CrossrefPubMedGoogle Scholar
  • 95 Gami AS, Hodge DO, Herges RM. et al. Obstructive sleep apnea, obesity, and the risk of incident atrial fibrillation. J Am Coll Cardiol 2007; 49 (05) 565-571
    CrossrefPubMedGoogle Scholar
  • 96 Cadby G, McArdle N, Briffa T. et al. Severity of OSA is an independent predictor of incident atrial fibrillation hospitalization in a large sleep-clinic cohort. Chest 2015; 148 (04) 945-952
    CrossrefPubMedGoogle Scholar
  • 97 Yamashita T, Murakawa Y, Sezaki K. et al. Circadian variation of paroxysmal atrial fibrillation. Circulation 1997; 96 (05) 1537-1541
    CrossrefPubMedGoogle Scholar
  • 98 Benjamin SE. Sleep in patients with neurologic disease. Continuum (Minneap Minn) 2020; 26 (04) 1016-1033
    PubMedGoogle Scholar
  • 99 Casetta I, Granieri E, Fallica E, la Cecilia O, Paolino E, Manfredini R. Patient demographic and clinical features and circadian variation in onset of ischemic stroke. Arch Neurol 2002; 59 (01) 48-53
    CrossrefPubMedGoogle Scholar
  • 100 Sahlin C, Sandberg O, Gustafson Y. et al. Obstructive sleep apnea is a risk factor for death in patients with stroke: a 10-year follow-up. Arch Intern Med 2008; 168 (03) 297-301
    CrossrefPubMedGoogle Scholar
  • 101 Kaneko Y, Hajek VE, Zivanovic V, Raboud J, Bradley TD. Relationship of sleep apnea to functional capacity and length of hospitalization following stroke. Sleep 2003; 26 (03) 293-297
    CrossrefPubMedGoogle Scholar
  • 102 Chien KL, Chen PC, Hsu HC. et al. Habitual sleep duration and insomnia and the risk of cardiovascular events and all-cause death: report from a community-based cohort. Sleep 2010; 33 (02) 177-184
    CrossrefPubMedGoogle Scholar
  • 103 Phillips B, Mannino DM. Do insomnia complaints cause hypertension or cardiovascular disease?. J Clin Sleep Med 2007; 3 (05) 489-494
    CrossrefPubMedGoogle Scholar
  • 104 Wu MP, Lin HJ, Weng SF, Ho CH, Wang JJ, Hsu YW. Insomnia subtypes and the subsequent risks of stroke: report from a nationally representative cohort. Stroke 2014; 45 (05) 1349-1354
    CrossrefPubMedGoogle Scholar
  • 105 Hermann DM, Bassetti CL. Role of sleep-disordered breathing and sleep-wake disturbances for stroke and stroke recovery. Neurology 2016; 87 (13) 1407-1416
    CrossrefPubMedGoogle Scholar
  • 106 Hermann DM, Bassetti CL. Sleep-related breathing and sleep-wake disturbances in ischemic stroke. Neurology 2009; 73 (16) 1313-1322
    CrossrefPubMedGoogle Scholar
  • 107 Hermann DM, Siccoli M, Brugger P. et al. Evolution of neurological, neuropsychological and sleep-wake disturbances after paramedian thalamic stroke. Stroke 2008; 39 (01) 62-68
    CrossrefPubMedGoogle Scholar
  • 108 Sterr A, Kuhn M, Nissen C. et al. Post-stroke insomnia in community-dwelling patients with chronic motor stroke: physiological evidence and implications for stroke care. Sci Rep 2018; 8 (01) 8409
    CrossrefPubMedGoogle Scholar
  • 109 Mims KN, Kirsch D. Sleep and stroke. Sleep Med Clin 2016; 11 (01) 39-51
    CrossrefPubMedGoogle Scholar
  • 110 Cai H, Wang XP, Yang GY. Sleep disorders in stroke: an update on management. Aging Dis 2021; 12 (02) 570-585
    CrossrefPubMedGoogle Scholar
  • 111 Vgontzas AN, Fernandez-Mendoza J, Liao D, Bixler EO. Insomnia with objective short sleep duration: the most biologically severe phenotype of the disorder. Sleep Med Rev 2013; 17 (04) 241-254
    CrossrefPubMedGoogle Scholar
  • 112 Vgontzas AN, Liao D, Bixler EO, Chrousos GP, Vela-Bueno A. Insomnia with objective short sleep duration is associated with a high risk for hypertension. Sleep 2009; 32 (04) 491-497
    CrossrefPubMedGoogle Scholar
  • 113 Chen JC, Brunner RL, Ren H. et al. Sleep duration and risk of ischemic stroke in postmenopausal women. Stroke 2008; 39 (12) 3185-3192
    CrossrefPubMedGoogle Scholar
  • 114 von Ruesten A, Weikert C, Fietze I, Boeing H. Association of sleep duration with chronic diseases in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study. PLoS One 2012; 7 (01) e30972
    CrossrefPubMedGoogle Scholar
  • 115 Helbig AK, Stöckl D, Heier M, Ladwig KH, Meisinger C. Symptoms of insomnia and sleep duration and their association with incident strokes: findings from the Population-Based MONICA/KORA Augsburg Cohort Study. PLoS One 2015; 10 (07) e0134480
    CrossrefPubMedGoogle Scholar
  • 116 Qureshi AI, Giles WH, Croft JB, Bliwise DL. Habitual sleep patterns and risk for stroke and coronary heart disease: a 10-year follow-up from NHANES I. Neurology 1997; 48 (04) 904-911
    CrossrefPubMedGoogle Scholar
  • 117 Leng Y, Cappuccio FP, Wainwright NW. et al. Sleep duration and risk of fatal and nonfatal stroke: a prospective study and meta-analysis. Neurology 2015; 84 (11) 1072-1079
    CrossrefPubMedGoogle Scholar
  • 118 He Q, Sun H, Wu X. et al. Sleep duration and risk of stroke: a dose-response meta-analysis of prospective cohort studies. Sleep Med 2017; 32: 66-74
    CrossrefPubMedGoogle Scholar
  • 119 Pan A, De Silva DA, Yuan JM, Koh WP. Sleep duration and risk of stroke mortality among Chinese adults: Singapore Chinese health study. Stroke 2014; 45 (06) 1620-1625
    CrossrefPubMedGoogle Scholar
  • 120 Ge B, Guo X. Short and long sleep durations are both associated with increased risk of stroke: a meta-analysis of observational studies. Int J Stroke 2015; 10 (02) 177-184
    CrossrefPubMedGoogle Scholar
  • 121 Brown DL, Feskanich D, Sánchez BN, Rexrode KM, Schernhammer ES, Lisabeth LD. Rotating night shift work and the risk of ischemic stroke. Am J Epidemiol 2009; 169 (11) 1370-1377
    CrossrefPubMedGoogle Scholar
  • 122 Kecklund G, Axelsson J. Health consequences of shift work and insufficient sleep. BMJ 2016; 355: i5210
    CrossrefPubMedGoogle Scholar
  • 123 Jackson CL, Redline S, Emmons KM. Sleep as a potential fundamental contributor to disparities in cardiovascular health. Annu Rev Public Health 2015; 36: 417-440
    CrossrefPubMedGoogle Scholar
  • 124 Troxel WM, DeSantis A, Richardson AS. et al. Neighborhood disadvantage is associated with actigraphy-assessed sleep continuity and short sleep duration. Sleep 2018; 41 (10) DOI: 10.1093/sleep/zsy140.
    CrossrefPubMedGoogle Scholar
  • 125 McEvoy RD, Antic NA, Heeley E. et al; SAVE Investigators and Coordinators. CPAP for prevention of cardiovascular events in obstructive sleep apnea. N Engl J Med 2016; 375 (10) 919-931
    CrossrefPubMedGoogle Scholar
  • 126 Khan SU, Duran CA, Rahman H, Lekkala M, Saleem MA, Kaluski E. A meta-analysis of continuous positive airway pressure therapy in prevention of cardiovascular events in patients with obstructive sleep apnoea. Eur Heart J 2018; 39 (24) 2291-2297
    CrossrefPubMedGoogle Scholar
  • 127 Brown DL, Durkalski V, Durmer JS. et al. Sleep for Stroke Management and Recovery Trial (Sleep SMART): rationale and methods. Int J Stroke 2020; 15 (08) 923-929
    CrossrefPubMedGoogle Scholar
  • 128 Kleindorfer DO, Towfighi A, Chaturvedi S. et al. 2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American Heart Association/American Stroke Association. Stroke 2021; 52 (07) e364-e467
    Google Scholar
  • 129 Kelly-Hayes M. Influence of age and health behaviors on stroke risk: lessons from longitudinal studies. J Am Geriatr Soc 2010; 58 (Suppl. 02) S325-S328
    CrossrefPubMedGoogle Scholar
  • 130 Braley TJ, Dunietz GL, Chervin RD, Lisabeth LD, Skolarus LE, Burke JF. Recognition and diagnosis of obstructive sleep apnea in older Americans. J Am Geriatr Soc 2018; 66 (07) 1296-1302
    CrossrefPubMedGoogle Scholar
  • 131 Brown DL, Jiang X, Li C. et al. Sleep apnea screening is uncommon after stroke. Sleep Med 2019; 59: 90-93
    CrossrefPubMedGoogle Scholar
  • 132 Saletu MT, Kotzian ST, Schwarzinger A, Haider S, Spatt J, Saletu B. Home sleep apnea testing is a feasible and accurate method to diagnose obstructive sleep apnea in stroke patients during in-hospital rehabilitation. J Clin Sleep Med 2018; 14 (09) 1495-1501
    CrossrefPubMedGoogle Scholar
  • 133 Chernyshev OY, McCarty DE, Moul DE. et al. A pilot study: portable out-of-center sleep testing as an early sleep apnea screening tool in acute ischemic stroke. Nat Sci Sleep 2015; 7: 127-138
    CrossrefPubMedGoogle Scholar
  • 134 Bravata DM, McClain V, Austin C. et al. Diagnosing and managing sleep apnea in patients with chronic cerebrovascular disease: a randomized trial of a home-based strategy. Sleep Breath 2017; 21 (03) 713-725
    CrossrefPubMedGoogle Scholar
  • 135 Takala M, Puustinen J, Rauhala E, Holm A. Pre-screening of sleep-disordered breathing after stroke: a systematic review. Brain Behav 2018; 8 (12) e01146
    CrossrefPubMedGoogle Scholar
  • 136 Gros P, Videnovic A. Overview of sleep and circadian rhythm disorders in Parkinson disease. Clin Geriatr Med 2020; 36 (01) 119-130
    CrossrefPubMedGoogle Scholar
  • 137 Dhawan V, Healy DG, Pal S, Chaudhuri KR. Sleep-related problems of Parkinson's disease. Age Ageing 2006; 35 (03) 220-228
    CrossrefPubMedGoogle Scholar
  • 138 Pagano G, De Micco R, Yousaf T, Wilson H, Chandra A, Politis M. REM behavior disorder predicts motor progression and cognitive decline in Parkinson disease. Neurology 2018; 91 (10) e894-e905
    CrossrefPubMedGoogle Scholar
  • 139 Berg D, Postuma RB, Adler CH. et al. MDS research criteria for prodromal Parkinson's disease. Mov Disord 2015; 30 (12) 1600-1611
    CrossrefPubMedGoogle Scholar
  • 140 Schenck CH, Boeve BF, Mahowald MW. Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series. Sleep Med 2013; 14 (08) 744-748
    CrossrefPubMedGoogle Scholar
  • 141 Chahine LM, Amara AW, Videnovic A. A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015. Sleep Med Rev 2017; 35: 33-50
    CrossrefPubMedGoogle Scholar
  • 142 Högl B, Stefani A, Videnovic A. Idiopathic REM sleep behaviour disorder and neurodegeneration - an update. Nat Rev Neurol 2018; 14 (01) 40-55
    CrossrefPubMedGoogle Scholar
  • 143 Kim Y, Kim YE, Park EO, Shin CW, Kim HJ, Jeon B. REM sleep behavior disorder portends poor prognosis in Parkinson's disease: a systematic review. J Clin Neurosci 2018; 47: 6-13
    CrossrefPubMedGoogle Scholar
  • 144 Zhang Y, Ren R, Sanford LD. et al. Sleep in Parkinson's disease: a systematic review and meta-analysis of polysomnographic findings. Sleep Med Rev 2020; 51: 101281
    CrossrefPubMedGoogle Scholar
  • 145 Stefani A, Högl B. Sleep in Parkinson's disease. Neuropsychopharmacology 2020; 45 (01) 121-128
    CrossrefPubMedGoogle Scholar
  • 146 Verbaan D, van Rooden SM, Visser M, Marinus J, van Hilten JJ. Nighttime sleep problems and daytime sleepiness in Parkinson's disease. Mov Disord 2008; 23 (01) 35-41
    CrossrefPubMedGoogle Scholar
  • 147 Leng Y, Musiek ES, Hu K, Cappuccio FP, Yaffe K. Association between circadian rhythms and neurodegenerative diseases. Lancet Neurol 2019; 18 (03) 307-318
    CrossrefPubMedGoogle Scholar
  • 148 Gros P, Mery VP, Lafontaine AL. et al. Obstructive sleep apnea in Parkinson's disease patients: effect of Sinemet CR taken at bedtime. Sleep Breath 2016; 20 (01) 205-212
    CrossrefPubMedGoogle Scholar
  • 149 Tsai CC, Wu MN, Liou LM, Chang YP. Levodopa reverse stridor and prevent subsequent endotracheal intubation in Parkinson disease patients with bilateral vocal cord palsy: a case report. Medicine (Baltimore) 2016; 95 (50) e5559
    CrossrefPubMedGoogle Scholar
  • 150 Bahia CMCS, Pereira JS, Lopes AJ. Laryngopharyngeal motor dysfunction and obstructive sleep apnea in Parkinson's disease. Sleep Breath 2019; 23 (02) 543-550
    CrossrefPubMedGoogle Scholar
  • 151 Mery VP, Gros P, Lafontaine AL. et al. Reduced cognitive function in patients with Parkinson disease and obstructive sleep apnea. Neurology 2017; 88 (12) 1120-1128
    CrossrefPubMedGoogle Scholar
  • 152 Kaminska M, Mery VP, Lafontaine AL. et al. Change in cognition and other non-motor symptoms with obstructive sleep apnea treatment in Parkinson disease. J Clin Sleep Med 2018; 14 (05) 819-828
    CrossrefPubMedGoogle Scholar
  • 153 Harmell AL, Neikrug AB, Palmer BW. et al. Obstructive sleep apnea and cognition in Parkinson's disease. Sleep Med 2016; 21: 28-34
    CrossrefPubMedGoogle Scholar
  • 154 Gómez-Esteban JC, Tijero B, Somme J. et al. Impact of psychiatric symptoms and sleep disorders on the quality of life of patients with Parkinson's disease. J Neurol 2011; 258 (03) 494-499
    CrossrefPubMedGoogle Scholar
  • 155 Avidan A, Hays RD, Diaz N. et al. Associations of sleep disturbance symptoms with health-related quality of life in Parkinson's disease. J Neuropsychiatry Clin Neurosci 2013; 25 (04) 319-326
    CrossrefPubMedGoogle Scholar
  • 156 Martinez-Martin P, Visser M, Rodriguez-Blazquez C, Marinus J, Chaudhuri KR, van Hilten JJ. SCOPA-Propark Group, ELEP Group. SCOPA-sleep and PDSS: two scales for assessment of sleep disorder in Parkinson's disease. Mov Disord 2008; 23 (12) 1681-1688
    CrossrefPubMedGoogle Scholar
  • 157 Trenkwalder C, Kohnen R, Högl B. et al. Parkinson's disease sleep scale – validation of the revised version PDSS-2. Mov Disord 2011; 26 (04) 644-652
    CrossrefPubMedGoogle Scholar
  • 158 Chaudhuri KR, Martinez-Martin P, Schapira AH. et al. International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease: the NMSQuest study. Mov Disord 2006; 21 (07) 916-923
    CrossrefPubMedGoogle Scholar
  • 159 Hurt CS, Rixon L, Chaudhuri KR, Moss-Morris R, Samuel M, Brown RG. Barriers to reporting non-motor symptoms to health-care providers in people with Parkinson's. Parkinsonism Relat Disord 2019; 64: 220-225
    CrossrefPubMedGoogle Scholar
  • 160 Loddo G, Calandra-Buonaura G, Sambati L. et al. The treatment of sleep disorders in Parkinson's disease: from research to clinical practice. Front Neurol 2017; 8: 42
    CrossrefPubMedGoogle Scholar
  • 161 Wallace DM, Wohlgemuth WK, Trotti LM. et al. Practical evaluation and management of insomnia in Parkinson's disease: a review. Mov Disord Clin Pract (Hoboken) 2020; 7 (03) 250-266
    CrossrefPubMedGoogle Scholar
  • 162 Espay AJ, Brundin P, Lang AE. Precision medicine for disease modification in Parkinson disease. Nat Rev Neurol 2017; 13 (02) 119-126
    CrossrefPubMedGoogle Scholar
  • 163 Kunz D, Stotz S, Bes F. Conversion to Parkinsonism and dementia in REM-sleep behavior disorder using the chronobiotic melatonin. medRxiv 2020; 2020.11.05.20224592. DOI: 10.1101/2020.11.05.20224592.
    CrossrefPubMedGoogle Scholar
  • 164 Fernández-Arcos A, Iranzo A, Serradell M, Gaig C, Santamaria J. The clinical phenotype of idiopathic rapid eye movement sleep behavior disorder at presentation: a study in 203 consecutive patients. Sleep 2016; 39 (01) 121-132
    CrossrefPubMedGoogle Scholar
  • 165 Postuma RB, Iranzo A, Hu M. et al. Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study. Brain 2019; 142 (03) 744-759
    CrossrefPubMedGoogle Scholar
  • 166 Galbiati A, Verga L, Giora E, Zucconi M, Ferini-Strambi L. The risk of neurodegeneration in REM sleep behavior disorder: a systematic review and meta-analysis of longitudinal studies. Sleep Med Rev 2019; 43: 37-46
    CrossrefPubMedGoogle Scholar
  • 167 Postuma RB, Berg D. Prodromal Parkinson's disease: the decade past, the decade to come. Mov Disord 2019; 34 (05) 665-675
    CrossrefPubMedGoogle Scholar
  • 168 Chahine LM, Iranzo A, Fernández-Arcos A. et al; PPMI Sleep Working Group. Basic clinical features do not predict dopamine transporter binding in idiopathic REM behavior disorder. NPJ Parkinsons Dis 2019; 5: 2
    CrossrefPubMedGoogle Scholar
  • 169 Crous-Bou M, Minguillón C, Gramunt N, Molinuevo JL. Alzheimer's disease prevention: from risk factors to early intervention. Alzheimers Res Ther 2017; 9 (01) 71
    CrossrefPubMedGoogle Scholar
  • 170 Brzecka A, Leszek J, Ashraf GM. et al. Sleep disorders associated with Alzheimer's disease: a perspective. Front Neurosci 2018; 12: 330
    CrossrefPubMedGoogle Scholar
  • 171 Marde VS, Atkare UA, Gawali SV. et al. Alzheimer's disease and sleep disorders: insights into the possible disease connections and the potential therapeutic targets. Asian J Psychiatr 2021; 102961 DOI: 10.1016/j.ajp.2021.102961.
    CrossrefPubMedGoogle Scholar
  • 172 Zhao Q-F, Tan L, Wang H-F. et al. The prevalence of neuropsychiatric symptoms in Alzheimer's disease: systematic review and meta-analysis. J Affect Disord 2016; 190: 264-271
    CrossrefPubMedGoogle Scholar
  • 173 Webster L, Costafreda Gonzalez S, Stringer A. et al. Measuring the prevalence of sleep disturbances in people with dementia living in care homes: a systematic review and meta-analysis. Sleep 2020; 43 (04) zsz251
    CrossrefPubMedGoogle Scholar
  • 174 Guarnieri B, Adorni F, Musicco M. et al. Prevalence of sleep disturbances in mild cognitive impairment and dementing disorders: a multicenter Italian clinical cross-sectional study on 431 patients. Dement Geriatr Cogn Disord 2012; 33 (01) 50-58
    CrossrefPubMedGoogle Scholar
  • 175 Sabia S, Fayosse A, Dumurgier J. et al. Association of sleep duration in middle and old age with incidence of dementia. Nat Commun 2021; 12 (01) 2289
    CrossrefPubMedGoogle Scholar
  • 176 Bubu OM, Brannick M, Mortimer J. et al. Sleep, cognitive impairment, and Alzheimer's disease: a systematic review and meta-analysis. Sleep 2017; 40 (01) DOI: 10.1093/sleep/zsw032.
    CrossrefPubMedGoogle Scholar
  • 177 Noble W, Spires-Jones TL. Sleep well to slow Alzheimer's progression?. Science 2019; 363 (6429): 813-814
    CrossrefPubMedGoogle Scholar
  • 178 Holth JK, Fritschi SK, Wang C. et al. The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans. Science 2019; 363 (6429): 880-884
    CrossrefPubMedGoogle Scholar
  • 179 Shokri-Kojori E, Wang GJ, Wiers CE. et al. β-Amyloid accumulation in the human brain after one night of sleep deprivation. Proc Natl Acad Sci U S A 2018; 115 (17) 4483-4488
    CrossrefPubMedGoogle Scholar
  • 180 Sharma RA, Varga AW, Bubu OM. et al. Obstructive sleep apnea severity affects amyloid burden in cognitively normal elderly. A longitudinal study. Am J Respir Crit Care Med 2018; 197 (07) 933-943
    CrossrefPubMedGoogle Scholar
  • 181 Liguori C, Mercuri NB, Izzi F. et al. Obstructive sleep apnea is associated with early but possibly modifiable Alzheimer's disease biomarkers changes. Sleep 2017; 40 (05) DOI: 10.1093/sleep/zsx011.
    CrossrefPubMedGoogle Scholar
  • 182 Cordone S, Scarpelli S, Alfonsi V, De Gennaro L, Gorgoni M. Sleep-based interventions in Alzheimer's disease: promising approaches from prevention to treatment along the disease trajectory. Pharmaceuticals (Basel) 2021; 14 (04) 383
    CrossrefPubMedGoogle Scholar
  • 183 Voysey ZJ, Barker RA, Lazar AS. The treatment of sleep dysfunction in neurodegenerative disorders. Neurotherapeutics 2021; 18 (01) 202-216
    CrossrefPubMedGoogle Scholar
  • 184 Cassidy-Eagle E, Siebern A, Unti L, Glassman J, O'Hara R. Neuropsychological Functioning in Older Adults with Mild Cognitive Impairment and Insomnia Randomized to CBT-I or Control Group. Neuropsychological functioning in older adults with mild cognitive impairment and insomnia randomized to CBT-I or control group. Clin Gerontol 2018; 41 (02) 136-144
    CrossrefPubMedGoogle Scholar
  • 185 Rubiño JA, Gamundí A, Akaarir M, Canellas F, Rial R, Nicolau MC. Bright light therapy and circadian cycles in institutionalized elders. Front Neurosci 2020; 14: 359
    CrossrefPubMedGoogle Scholar
  • 186 Barrick AL, Sloane PD, Williams CS. et al. Impact of ambient bright light on agitation in dementia. Int J Geriatr Psychiatry 2010; 25 (10) 1013-1021
    CrossrefPubMedGoogle Scholar
  • 187 Figueiro MG, Plitnick B, Roohan C, Sahin L, Kalsher M, Rea MS. Effects of a tailored lighting intervention on sleep quality, rest-activity, mood, and behavior in older adults with Alzheimer disease and related dementias: a randomized clinical trial. J Clin Sleep Med 2019; 15 (12) 1757-1767
    CrossrefPubMedGoogle Scholar
  • 188 Figueiro MG, Sahin L, Kalsher M, Plitnick B, Rea MS. Long-term, all-day exposure to circadian-effective light improves sleep, mood, and behavior in persons with dementia. J Alzheimers Dis Rep 2020; 4 (01) 297-312
    CrossrefPubMedGoogle Scholar
  • 189 O'Caoimh R, Mannion H, Sezgin D, O'Donovan MR, Liew A, Molloy DW. Non-pharmacological treatments for sleep disturbance in mild cognitive impairment and dementia: a systematic review and meta-analysis. Maturitas 2019; 127: 82-94
    CrossrefPubMedGoogle Scholar
  • 190 McCurry SM, Gibbons LE, Logsdon RG, Vitiello MV, Teri L. Nighttime insomnia treatment and education for Alzheimer's disease: a randomized, controlled trial. J Am Geriatr Soc 2005; 53 (05) 793-802
    CrossrefPubMedGoogle Scholar
  • 191 McCurry SM, Pike KC, Vitiello MV, Logsdon RG, Larson EB, Teri L. Increasing walking and bright light exposure to improve sleep in community-dwelling persons with Alzheimer's disease: results of a randomized, controlled trial. J Am Geriatr Soc 2011; 59 (08) 1393-1402
    CrossrefPubMedGoogle Scholar
  • 192 Salami O, Lyketsos C, Rao V. Treatment of sleep disturbance in Alzheimer's dementia. Int J Geriatr Psychiatry 2011; 26 (08) 771-782
    CrossrefPubMedGoogle Scholar
  • 193 Venturelli M, Sollima A, Cè E. et al. Effectiveness of exercise- and cognitive-based treatments on salivary cortisol levels and sundowning syndrome symptoms in patients with Alzheimer's disease. J Alzheimers Dis 2016; 53 (04) 1631-1640
    CrossrefPubMedGoogle Scholar
  • 194 Ancoli-Israel S, Palmer BW, Cooke JR. et al. Cognitive effects of treating obstructive sleep apnea in Alzheimer's disease: a randomized controlled study. J Am Geriatr Soc 2008; 56 (11) 2076-2081
    CrossrefPubMedGoogle Scholar
  • 195 Cooke JR, Ancoli-Israel S, Liu L. et al. Continuous positive airway pressure deepens sleep in patients with Alzheimer's disease and obstructive sleep apnea. Sleep Med 2009; 10 (10) 1101-1106
    CrossrefPubMedGoogle Scholar
  • 196 Cooke JR, Ayalon L, Palmer BW. et al. Sustained use of CPAP slows deterioration of cognition, sleep, and mood in patients with Alzheimer's disease and obstructive sleep apnea: a preliminary study. J Clin Sleep Med 2009; 5 (04) 305-309
    CrossrefPubMedGoogle Scholar
  • 197 Troussière AC, Charley CM, Salleron J. et al. Treatment of sleep apnoea syndrome decreases cognitive decline in patients with Alzheimer's disease. J Neurol Neurosurg Psychiatry 2014; 85 (12) 1405-1408
    CrossrefPubMedGoogle Scholar
  • 198 Kushida CA, Nichols DA, Holmes TH. et al. Effects of continuous positive airway pressure on neurocognitive function in obstructive sleep apnea patients: the Apnea Positive Pressure Long-term Efficacy Study (APPLES). Sleep 2012; 35 (12) 1593-1602
    CrossrefPubMedGoogle Scholar
  • 199 Rosenzweig I, Glasser M, Crum WR. et al. Changes in neurocognitive architecture in patients with obstructive sleep apnea treated with continuous positive airway pressure. EBioMedicine 2016; 7: 221-229
    CrossrefPubMedGoogle Scholar
  • 200 Gehrman P, Gooneratne NS, Brewster GS, Richards KC, Karlawish J. Impact of Alzheimer disease patients' sleep disturbances on their caregivers. Geriatr Nurs 2018; 39 (01) 60-65
    CrossrefPubMedGoogle Scholar
  • 201 Okuda S, Tetsuka J, Takahashi K, Toda Y, Kubo T, Tokita S. Association between sleep disturbance in Alzheimer's disease patients and burden on and health status of their caregivers. J Neurol 2019; 266 (06) 1490-1500
    CrossrefPubMedGoogle Scholar