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Synlett 2023; 34(03): 283-287
DOI: 10.1055/a-1970-8386
DOI: 10.1055/a-1970-8386
letter
An Efficient Enantioselective Total Synthesis of Atorvastatin Calcium
Abstract
A concise and efficient asymmetric synthesis of tert-butyl [(4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate is presented. This key chiral-chain precursor of atorvastatin was synthesized from a commercially available inexpensive starting material, and was converted into atorvastatin calcium. The synthesis has the potential for scale up, and could be used to produce atorvastatin calcium on an industrial scale.
Key words
total synthesis - statins - atorvastatin calcium - Paal–Knorr Reaction - enantioselectivitySupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1970-8386.
- Supporting Information
Publication History
Received: 24 September 2022
Accepted after revision: 02 November 2022
Accepted Manuscript online:
02 November 2022
Article published online:
25 November 2022
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