674 Cases of Late Postoperative Intraocular Lens Opacification of a Hydrophilic-Hydrophobic Acryl Intraocular Lens in Switzerland and Retrospective Opacification Risk Factor Assessment of 212 Cases

Abstract

Purpose To report the prevalence of late postoperative opacification of a hydrophilic and hydrophobic acrylic intraocular lens (IOL) and to assess the risk factors in a subset of 212 eyes of patients referred to the University Eye Department in Basel, Switzerland.

Design Retrospective case series.

Methods A survey was performed at all large ophthalmological clinics in Switzerland regarding exchanged Lentis LS-502-1 lenses, and the number of affected eyes was counted. Moreover, consecutive patients who were referred to a tertiary clinic between September 2015 and November 2016 with Lentis LS-502-1 opacification were investigated. Peri- and postoperative charts, medical history, and topical and systemic medications were assessed.

Results A total of 674 opacified Lentis LS-502-1 lenses have been reported in Switzerland, and 212 consecutive eyes of 182 patients were included in the study. All IOLs had a similar pattern of opacification with a yellowish, diffuse appearance, and most of them showed a small, paracentral, roundish area that was less affected or not at all. Arterial hypertension (73%), hypercholesterolemia (34%), and diabetes (21%) were the main associated systemic diseases, and statins (34%) and betablockers (34%) were the main treatments used.

Conclusions The prevalence of IOL opacification was 9.9%. No associated systemic eye disease or medications could be detected, which was implicated in the opacification process. The reason for opacification remains unclear, but it seems to be unrelated to the patientʼs state; therefore, it is attributed to primary calcification.

Zusammenfassung

Hintergrund Evaluierung der Prävalenz einer späten postoperativen Eintrübung einer hydrophilen und hydrophoben intraokularen Acryl-Linse (IOL) in der Schweiz und Beurteilung der Risikofaktoren in einer Untergruppe von 212 Augen von Patienten, welche and die Augenklinik des Universitätsspitals Basel überwiesen wurden.

Material und Methoden Nach Umfrage in allen grossen ophthalmologischen Kliniken der Schweiz hinsichtlich ausgetauschten Lentis LS-502-1 IOLs wurde die Anzahl der betroffenen Augen retrospektiv eruiert. Überdies wurde in einer Untergruppe dieser Patienten, welche zwischen September 2015 bis November 2016 ans Universitätsspital Basel überwiesen wurden, Daten hinsichtlich peri- und post-operativem Verlauf, systemischen und okulären Erkrankungen und Therapien erfasst.

Ergebnisse Insgesamt wurden 674 eingetrübte Lentis LS-502-1 IOLs in der Schweiz gemeldet, wovon 212 (182 Patienten) in der besagten Zeitspanne genauer untersucht wurden. Alle IOLs wiesen ein ähnliches Trübungsmuster mit einem gelblichen, diffusen Erscheinungsbild auf, und die meisten von ihnen wiesen einen kleinen, parazentralen, rundlichen Bereich der weniger oder gar nicht betroffen war. Arterielle Hypertonie (73%), Hypercholesterinämie (34%) und Diabetes (21%) waren die wichtigsten assoziierten Systemerkrankungen, und Statine (34%) und Statine (34%) und Betablocker (34%) waren die am häufigsten verwendeten Medikamente.

Schlussfolgerungen Die Prävalenz der IOL-Trübung lag bei 9,9%. Es konnten keine systemischen Augenkrankheiten oder Medikamente festgestellt werden, die an der Trübung beteiligt waren. Der Grund für die Eintrübung bleibt unklar und wird somit auf eine primäre Verkalkung zurückgeführt.

Key words

intraocular lens - opacification - intraocular lens exchange

Schlüsselwörter

Intraokularlinsen - Eintrübung - Intraokularlinsenwechsel

Publication History

Received: 26 September 2021

Accepted: 05 January 2023

Article published online:
25 April 2023

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