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DOI: 10.1055/a-2021-7993
Investigations on Biomimetic Dimerization in Natural Product Synthesis
We are grateful for financial support from the National Natural Science Foundation of China (22071192, 21772153) and the Shaanxi Provincial Science and Technology Department (2019JM-151).
Abstract
Biomimetic dimerization is a fascinating pathway to natural product synthesis. By using structurally inferior monomers, complex molecular architectures can be readily established with distinct efficiency and elegance. In this Account, our investigation on biomimetic dimerization in natural product synthesis has been summarized, which includes our synthetic exploration of linderaspirone A, bi-linderone, parvistemin A, (±)-diperezone, scabellone B, and spiroxins A/C/D.
1 Introduction
2 Biomimetic Dimerization in the Synthesis of Linderaspirone A and Bi-linderone
3 Biomimetic Dimerization in the Synthesis of Parvistemin A and (±)-Diperezone
4 Biomimetic Dimerization in the Synthesis of Scabellone B
5 Dimerization Investigation in the Synthesis of Spiroxins A/C/D
6 Conclusion
Key words
biomimetic synthesis - bioactivity - dimerization - natural product - biosynthetic proposal - oxidative coupling - oxo-6π electrocyclizationPublication History
Received: 07 December 2022
Accepted after revision: 28 January 2023
Accepted Manuscript online:
28 January 2023
Article published online:
28 February 2023
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For selected reviews on the biomimetic synthesis of natural products, please see:
For selected reviews on natural product synthesis through biomimetic dimerization, please see:
For selected reviews on biomimetic Diels–Alder reaction in natural product synthesis, please see: