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Synlett 2023; 34(10): 1098-1112
DOI: 10.1055/a-2060-3288
DOI: 10.1055/a-2060-3288
account
Dispersion Effects
Understanding and Describing London Dispersion Effects in Transition-Metal-Catalyzed C–H Activations
Generous support from the European Research Council (ERC Advanced Grant No.101021358), the Deutsche Forschungsgemeinschaft (DFG, Gottfried Wilhelm Leibniz Prize (L.A.)), the China Scholarship Council (CSC, fellowship to B.Y.) and the Deutsche Forschungsgemeinschaft (DFG, SPP 1807) on ‘Control of London Dispersion Interactions in Molecular Chemistry’ are gratefully acknowledged.
Abstract
Transition-metal-catalyzed C–H activation has emerged as a powerful strategy for molecular synthesis with unique levels of resource economy. Weak secondary dispersion interactions were found to play an essential role in these transformations in terms of kinetic efficacy and selectivity. This Account summarizes our group’s recent progress in the rationalization and quantification of London dispersion effects within the transition-metal-catalyzed C–H activation.
1 Introduction
2 Annulation Reactions
3 Alkylation Reactions
4 Arylation Reactions
5 Olefination Reactions
6 Oxygenation Reactions
7 Conclusion
Key words
C–H activation - London dispersion effect - DFT calculations - transition metals - catalysisPublication History
Received: 27 February 2023
Accepted after revision: 22 March 2023
Accepted Manuscript online:
22 March 2023
Article published online:
09 May 2023
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For selected reviews on C–H activation, see: