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DOI: 10.1055/a-2107-4492
Molybdenum-Mediated One-Pot Synthesis of 2-Hydroxypyrimidines from Isoxazoles
Abstract
A one-pot procedure towards substituted 2-hydroxypyrimidines from commercially available isoxazoles is reported. The process involves cleavage of the isoxazole N–O bond mediated by Mo2(OAc)4, then in situ hydrolysis of the resulting β-amino enone to the reactive 1,3-dicarbonylated intermediate, followed by hydroxypyrimidine formation in the presence of urea. Moderate to excellent yields are obtained, leading to functionalized hydroxypyrimidines. By using readily available isoxazoles, a wide range of new diverse polysubstituted hydroxypyrimidines may be prepared by this method.
Key words
isoxazoles - N–O bond cleavage - hydroxypyrimidines - molybdenum - one-pot - β-amino enones - 1,3-diketonesSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2107-4492.
- Supporting Information
Publication History
Received: 10 May 2023
Accepted: 07 June 2023
Accepted Manuscript online:
07 June 2023
Article published online:
01 August 2023
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