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Klin Monbl Augenheilkd 2024; 241(04): 551-553
DOI: 10.1055/a-2218-8352
Der interessante Fall

A Difficult Case of Optic Neuropathy: Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)

Ein schwieriger Fall optischer Neuropathie: Myelin-Oligodendrozyten-Glykoprotein-Antikörper-assoziierte Erkrankung (MOGAD)
Celine Noha Haeller
1   Ophthalmology, HFR, Fribourg, Switzerland
,
Thierry Badoux
2   Neurology, HFR, Fribourg, Switzerland
,
Friedrich Medlin
2   Neurology, HFR, Fribourg, Switzerland
,
Lionel Arlettaz
3   Allergology and Clinical Immunology, Hôpital du Valais, Sion, Switzerland
,
Philippe DeGottrau
1   Ophthalmology, HFR, Fribourg, Switzerland
,
Eva Grams
1   Ophthalmology, HFR, Fribourg, Switzerland
,
Manolito Lucas Finger
1   Ophthalmology, HFR, Fribourg, Switzerland
,
Vincent Dunet
4   Medical Radiology, CHUV, Lausanne, Switzerland
,
Marie-Claire Gaillard
1   Ophthalmology, HFR, Fribourg, Switzerland
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Background

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a recently defined inflammatory demyelinating disease, that generally affects the optic nerve (ON) in adults and the central nervous system in children [1], [2]. The specific clinical phenotype, radiological findings, and neurological manifestations enable its distinction from other central nervous system inflammatory demyelinating diseases (CNS IDDs) such as aquaporine-4-IgGQ neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) [3] [4] [5].



Publication History

Received: 27 October 2023

Accepted: 27 November 2023

Article published online:
23 April 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
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  • References

  • 1 Messias K, Marques VD, Messias A. Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis: an update. Arq Bras Oftalmol 2022; 86: 83-92
    CrossrefPubMedSearch in Google Scholar
  • 2 Banwell B, Bennett JL, Marignier R. et al. Diagnosis of myelin oligodendrocyte glycoprotein antibody-associated disease: International MOGAD Panel proposed criteria. Lancet Neurol 2023; 22: 268-282
    CrossrefPubMedSearch in Google Scholar
  • 3 Sechi E, Cacciaguerra L, Chen JJ. et al. Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD): A Review of Clinical and MRI Features, Diagnosis, and Management. Front Neurol 2022; 13: 885218
    CrossrefPubMedSearch in Google Scholar
  • 4 Chen JJ, Flanagan EP, Jitprapaikulsan J. et al. Myelin Oligodendrocyte Glycoprotein Antibody–Positive Optic Neuritis: Clinical Characteristics, Radiologic Clues, and Outcome. Am J Ophthalmol 2018; 195: 8-15
    CrossrefPubMedSearch in Google Scholar
  • 5 Foo R, Yau C, Singhal S. et al. Optic Neuritis in the Era of NMOSD and MOGAD: A Survey of Practice Patterns in Singapore. Asia Pac J Ophthalmol (Phila) 2022; 11: 184-195
    CrossrefPubMedSearch in Google Scholar
  • 6 Cobo-Calvo A, Sepúlveda M, Rollot F. et al. Evaluation of treatment response in adults with relapsing MOG-Ab-associated disease. J Neuroinflammation 2019; 16: 134
    CrossrefPubMedSearch in Google Scholar
  • 7 Jarius S, Ruprecht K, Kleiter I. et al. MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome. J Neuroinflammation 2016; 13: 280
    CrossrefPubMedSearch in Google Scholar
  • 8 Lopez JA, Houston SD, Tea F. et al. Validation of a Flow Cytometry Live Cell-Based Assay to Detect Myelin Oligodendrocyte Glycoprotein Antibodies for Clinical Diagnostics. J Appl Lab Med 2022; 7: 12-25
    CrossrefPubMedSearch in Google Scholar
  • 9 Waters PJ, Komorowski L, Woodhall M. et al. A multicenter comparison of MOG-IgG cell-based assays. Neurology 2019; 92: e1250-e1255
    CrossrefPubMedSearch in Google Scholar