Synlett 2024; 35(07): 821-825
DOI: 10.1055/a-2229-1887
letter

Ligand-Free Copper(I) Chloride Catalyzed N-Arylation of 1,2,4-Triazole with Aryl Bromides

WeiZhi Ang
,
Chloe Kah-Yee Low
,
Yong-Chua Teo
We would like to thank Nanyang Technological University (RI 2/21 TYC) for funding this work.


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Abstract

An efficient protocol was developed for the N-arylation of 1,2,4-triazole by using substituted aryl bromides catalyzed by CuCl under ligand-free conditions. This method afforded the products in good to excellent yields (up to 88%) under the optimized conditions.

Supporting Information



Publication History

Received: 22 September 2023

Accepted after revision: 13 December 2023

Accepted Manuscript online:
13 December 2023

Article published online:
18 January 2024

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