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Synlett 2024; 35(14): 1703-1706
DOI: 10.1055/a-2236-9522
DOI: 10.1055/a-2236-9522
letter
Condensation of Amines with S-Methyl Thiouronium Salts: Another Entry for the Synthesis of Amidines
We thank the Yıldız Technical University for partial funding of the project (Grant No. FCD-2021-3892).
Dedicated to Professor H. Ila on the occasion of her 79th birthday
Abstract
We present a condensation of primary aryl or alkyl amines with S-methyl thiouronium salts to obtain N,N,N′-trisubstituted amidines. High yields, short reaction times, and a fair substrate scope are the noteworthy features of this protocol. Surprisingly, the reaction of a thiouronium salt with 4-aminopyridine gave 1-(4-methoxybenzoyl)piperidine.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2236-9522.
- Supporting Information
Publication History
Received: 09 September 2023
Accepted after revision: 02 January 2024
Accepted Manuscript online:
02 January 2024
Article published online:
24 January 2024
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